A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

Table 4 Cardiac structure and global function in CKD

	Healthy Controls (n = 20)	Mild CKD (n = 40)	Moderate CKD (n = 40)	Severe CKD (n = 20)	P-value
LVEDV (ml/m²)	74 ± 11	68 ± 9.1	68 ± 10	65 ± 9.7	0.03
LVESV (ml/m²)^a	23 ± 1.3	21 ± 1.3	20 ± 1.3	19 ± 1.3	0.13
LVSV (ml/m²)^a	50 ± 1.1	46 ± 1.1	47 ± 1.2	46 ± 1.2	0.18
EF (%)	68 ± 4.6	68 ± 6.1	69 ± 6.7	70 ± 5.8	0.72
LVMht^2.7 (g/m^2.7)^a	21 ± 1.2	21 ± 1.3	22 ± 1.2	25 ± 1.2	0.12
MVR (g/ml)	0.7 ± 0.1	0.72 ± 0.16	0.75 ± 0.16	0.87 ± 0.17	0.003
RA Area (cm²/m²)	12 ± 1.8	12 ± 1.9	11 ± 2.5	11 ± 2	0.69
LA Area (cm²/m²)^a	12 ± 1.3	12 ± 1.2	11 ± 1.2	11 ± 1.2	0.38

Bonferroni correction applied- p < 0.006 is considered significant
Abbreviations: CKD chronic kidney disease, LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, LVSV left ventricular stroke volume, EF ejection fraction, LVMht(2.7) left ventricular mass indexed to height to the power of 2.7, MVR left ventricular mass to volume ratio
^aLogarithmic transformation was applied

ISSN: 1532-429X