A comprehensive characterization of myocardial and vascular phenotype in pediatric chronic kidney disease using cardiovascular magnetic resonance imaging

Table 6 Tissue Phase Mapping in CKD

	Healthy Controls (n = 20)	Mild CKD (n = 40)	Moderate CKD (n = 40)	Severe CKD (n = 20)	P-value
Rad S′ (cm/s)	2.7 ± 0.31	2.6 ± 0.24	2.5 ± 0.38	2.4 ± 0.31	0.003
Rad E’ (cm/s)	4.2 ± 0.59	3.6 ± 0.62	3.4 ± 0.78	3.3 ± 0.53	< 0.001
Rad A’ (cm/s)	1.3 ± 0.35	1.1 ± 0.34	1.2 ± 0.31	1.2 ± 0.28	0.30
Long S′ (cm/s)	4.6 ± 1.6	3.9 ± 1.1	3.4 ± 1.3	3.6 ± 1.3	0.009
Long E’ (cm/s)	7.9 ± 1.5	7.5 ± 2.0	6.7 ± 1.8	6.8 ± 1.4	0.046
Long A’ (cm/s)	2.3 ± 0.71	2.5 ± 1.1	2.7 ± 0.85	2.5 ± 0.64	0.61
Long E’/A’ ratio^a	3.4 ± 1.3	3.2 ± 1.6	2.6 ± 1.4	2.8 ± 1.3	0.003^†
Long E/E’ ratio^a	6 ± 1.2	6.7 ± 1.3	7.5 ± 1.4	7.3 ± 1.4	0.03

Bonferroni correction applied- p < 0.006 is considered significant
Abbreviations: CKD chronic kidney disease, Rad radial, Long longitudinal, S′ systolic myocardial velocity, E’ early diastolic myocardial velocity, A’ late diastolic myocardial velocity, E’/A’ E’ over A’ ratio, E/E’ E over E’ ratio
^aLogarithmic transformation was applied
^†ANOVA Welch (W) test was used

ISSN: 1532-429X