Skip to main content

Table 2 Echocardiographic and CMR parameters of HFpEF patients and age- and sex-matched controls

From: Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction

 

HFpEF (n = 118)

Healthy Controls (n = 26)

P

Echocardiography

 LV ejection fraction (%)

64 ± 7

64 ± 5

0.93

 Transmitral peak E velocity max (m/s)

91 ± 29

55 ± 9

< 0.001

 Transmitral E deceleration time (ms)

160 ± 62

197 ± 35

0.004

 E/e’ septal ratio

18.1 ± 7.3

9.4 ± 1.7

< 0.001

 RV/RA gradient (mmHg)

32 ± 11

19 ± 5

< 0.001

 RA volume index (ml/m2)

35 ± 20

18 ± 5

< 0.001

 RV fractional area change (%)

41 ± 9

47 ± 8

0.008

 RV FAC ≤ 35% (n, %)

32 (27)

0 (0)

< 0.001

 TAPSE (mm)

19 ± 5

24 ± 4

< 0.001

 TAPSE≤16 mm (n, %)

47 (40)

1 (4)

< 0.001

Cardiac MR

 LVM index (g/m2)

68 ± 15

58 ± 12

0.003

 LV EDV index (ml/m2)

73 ± 18

63 ± 11

0.006

 LVEF (%)

63 ± 8

67 ± 5

0.024

 RV EDV index (ml/m2)

82 ± 28

67 ± 11

0.005

 RVEF (%)

57 ± 9

60 ± 6

0.052

 RVEF≤45% (n, %)

16 (14)

2 (8)

0.41

 LV mass/volume ratio

0.96 ± 0.20

0.94 ± 0.19

0.71

 LA volume index (ml)

66 ± 29

32 ± 10

< 0.001

 Myocardium native T1 time (ms)

1109 ± 82

1144 ± 47

0.038

 Myocardium post contrast T1 time (ms)

353 ± 56

381 ± 64

0,028

 ECV (%)

32.9 ± 4.8

28.2 ± 2.4

< 0.001

 Lambda coefficient

0.52 ± 0.08

0.49 ± 0.05

0.051

 ECV ≥ 33% (n, %)

49 (42)

0 (0)

< 0.001

 Late gadolinium enhancement (n, %)

26 (22)

0 (0)

0.022

  1. Values are mean ± SD. LA left atrium, LV left ventricle, RV right ventricle, RA right atrium, BMI body mass index
  2. TAPSE tricuspid annular plane systolic excursion, LVM left ventricular mass, EF ejection fraction, EDV end-diastolic volume, ECV extracellular volume