Skip to main content

Table 3 Baseline characteristics of HFpEF patients with ECV < or ≥ 33%

From: Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction

  HFpEF with ECV < 33% (n = 68) HFpEF with ECV ≥ 33% (n = 49) P
Baseline characteristics
 Age (years) 78 ± 8 79 ± 9 0.49
 Body mass index (kg/m2) 30 ± 7 28 ± 7 0.082
 Female (n, %) 41 (60) 33 (67) 0.44
 Systolic blood pressure (mmHg) 137 ± 21 135 ± 21 0.54
 Diastolic blood pressure (mmHg) 76 ± 12 74 ± 14 0.45
 NYHA functional class III-IV (n, %) 28 (41) 24 (49) 0.57
Laboratory characteristics
 eGFR (ml/min/1.73 m2) 58 ± 20 60 ± 28 0.56
 Hemoglobin (g/dl) 12.1 ± 1.8 11.3 ± 2.0 0.020
 NT-proBNP (pg/ml) 1584[432; 34,306] £ 1889 [374; 27,736] £ 0.40
Medical history
 Atrial fibrillation (n, %) 42 (62) 30 (61) 0.90
 Ischemic cardiomyopathy (n, %) 23 (34) 16 (33) 0.94
 Previous valvular surgery (n, %) 8 (12) 4 (8) 0.76
Cardiovascular risk factors
 Smoking (n, %) 29 (43) 18 (37) 0.52
 Hypertension (n, %) 64 (94) 44 (92) 0.37
 Diabetes (n, %) 22 (33) 24 (49) 0.069
 Family history of cardiovascular disease (n, %) 14 (21) 10 (20) 0.98
 Hypercholesterolemia (n, %) 47 (70) 30 (61) 0.29
Echocardiography
 Left ventricular ejection fraction (%) 64 ± 7 63 ± 8 0.66
 Transmitral peak E velocity max (m/s) 86 ± 29 98 ± 26 0.025
 Transmitral E deceleration time (ms) 155 ± 62 167 ± 63 0.35
 E/e’ septal ratio 16 ± 6 20 ± 8 0.004
 RV/RA gradient (mmHg) 31 ± 11 34 ± 11 0.13
 RA volume index (ml/m2) 34 ± 19 36 ± 22 0.75
 RV fractional area change (%) 42 ± 8 42 ± 11 0.84
 TAPSE (mm) 19 ± 5 18 ± 5 0.11
Cardiac MR
 LVM index (g/m2) 67 ± 14 66 ± 16 0.81
 LV EDV index (ml/m2) 71 ± 16 72 ± 20 0.58
 LVEF (%) 63 ± 8 63 ± 8 0.997
 RV EDV index (ml/m2) 77 ± 22 86 ± 32 0.097
 RVEF (%) 56 ± 7 56 ± 10 0.98
 RVEF≤45% (n, %) 6 (9) 10 (20) 0.073
 LV mass/volume ratio 0.97 ± 0.21 0.94 ± 0.19 0.43
 LA volume index (ml/m2) 65 ± 29 68 ± 28 0.68
 Myocardium native T1 time (ms) 1109 ± 83 1107 ± 82 0.88
 Myocardium post contrast T1 time (ms) 362 ± 58 340 ± 52 0.036
 ECV (%) 30.0 ± 2.2 37.0 ± 4.3 < 0.001
 Lambda coefficient 0.48 ± 0.05 0.57 ± 0.08 < 0.001
 Late gadolinium enhancement 13 (19) 13 (28) 0.29
  1. Values are mean ± SD. £: median (min, max); LA left atrium, LV left ventricle, RV right ventricle, RA right atrium, BMI body mass index, TAPSE tricuspid annular plane systolic excursion, LVM left ventricular mass, EF ejection fraction, EDV end-diastolic volume, ECV extracellular volume