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Table 4 Univariate Cox analysis for composite event (death and first HF)

From: Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction

  Composite outcome (death or first HF)
HR [95%IC] P
Age (years) 1.00 [0.96; 1.04] 0.96
Body surface area (m2) 0.29 [0.08; 1.08] 0.065
Female (n, %) 1.63 [0.79; 3.36] 0.19
Heart rate (bpm) 1.02 [1.00; 1.04] 0.086
Systolic blood pressure (mmHg) 0.99 [0.97; 1.01] 0.18
Diastolic blood pressure (mmHg) 0.97 [0.95; 1.00] 0.064
NYHA functional class III-IV 1.18 [0.62; 2.26] 0.62
Laboratory characteristics
 eGFR (ml/min/1.73 m2) 0.98 [0.96; 0.99] 0.040
 Hemoglobin (g/dl) 0.80 [0.66; 0.96] 0.020
 NT-proBNP (pg/ml) 1.12 [0.82; 1.55] 0.48
Medical history
 Atrial fibrillation (n, %) 1.15 [0.58; 2.25] 0.69
 Ischemic cardiomyopathy (n, %) 1.03 [0.52; 2.04] 0.94
 Previous valvular surgery (n, %) 1.16 [0.35; 3.83] 0.81
 Previous heart failure episode 1.17 [0.50; 2.73] 0.72
Cardiovascular risk factors
 Smoking (n, %) 0.99 [0.51; 1.92] 0.98
 Hypertension (n, %) 0.81 [0.25; 2.68] 0.73
 Diabetes (n, %) 2.15 [1.13; 4.08] 0.020
 Family history of cardiovascular disease (n, %) 0.97 [0.45; 2.12] 0.94
 Hypercholesterolemia (n, %) 1.04 [0.51; 2.11] 0.91
Echocardiography
 LV ejection fraction (%) 1.03 [0.98; 1.08] 0.20
 Transmitral peak E velocity max (m/s) 1.01 [1.00; 1.02] 0.025
 E/e’ septal ratio 1.02 [0.98; 1.06] 0.42
 RV/RA gradient (mmHg) 1.01 [0.98; 1.04] 0.60
 RA volume index (ml/m2) 1.00 [0.99; 1.02] 0.53
 RV fractional area change (%) 2.01 [0.06; 73.25] 0.70
 TAPSE (mm) 0.94 [0.89; 1.00] 0.064
Cardiac MR
 LVM index (g/m2) 0.99 [0.98; 1.01] 0.62
 LV EDV index (ml/m2) 0.99 [0.98; 1.01] 0.58
 LVEF (%) 1.03 [0.99; 1.07] 0.19
 RV EDV index (ml/m2) 1.00 [0.99; 1.01] 0.59
 RVEF (%) 0.99 [0.96; 1.04] 0.81
 LV mass/volume ratio 1.24 [0.06; 25.3] 0.89
 LA volume index (ml/m2) 1.00 [0.98; 1.02] 0.87
 Myocardium native T1 (ms) 1.01 [0.99; 1.01] 0.23
 ECV (%) 1.07 [1.01; 1.12] 0.015
 ECV ≥ 33% 2.62 [1.35; 5.09] 0.005
 LGE (%) 1.08 [0.96; 1.21] 0.22