Table 4 Univariate Cox analysis for composite event (death and first HF)
| Â | Composite outcome (death or first HF) | |
|---|---|---|
HR [95%IC] | P | |
Age (years) | 1.00 [0.96; 1.04] | 0.96 |
Body surface area (m2) | 0.29 [0.08; 1.08] | 0.065 |
Female (n, %) | 1.63 [0.79; 3.36] | 0.19 |
Heart rate (bpm) | 1.02 [1.00; 1.04] | 0.086 |
Systolic blood pressure (mmHg) | 0.99 [0.97; 1.01] | 0.18 |
Diastolic blood pressure (mmHg) | 0.97 [0.95; 1.00] | 0.064 |
NYHA functional class III-IV | 1.18 [0.62; 2.26] | 0.62 |
Laboratory characteristics | ||
 eGFR (ml/min/1.73 m2) | 0.98 [0.96; 0.99] | 0.040 |
 Hemoglobin (g/dl) | 0.80 [0.66; 0.96] | 0.020 |
 NT-proBNP (pg/ml) | 1.12 [0.82; 1.55] | 0.48 |
Medical history | ||
 Atrial fibrillation (n, %) | 1.15 [0.58; 2.25] | 0.69 |
 Ischemic cardiomyopathy (n, %) | 1.03 [0.52; 2.04] | 0.94 |
 Previous valvular surgery (n, %) | 1.16 [0.35; 3.83] | 0.81 |
 Previous heart failure episode | 1.17 [0.50; 2.73] | 0.72 |
Cardiovascular risk factors | ||
 Smoking (n, %) | 0.99 [0.51; 1.92] | 0.98 |
 Hypertension (n, %) | 0.81 [0.25; 2.68] | 0.73 |
 Diabetes (n, %) | 2.15 [1.13; 4.08] | 0.020 |
 Family history of cardiovascular disease (n, %) | 0.97 [0.45; 2.12] | 0.94 |
 Hypercholesterolemia (n, %) | 1.04 [0.51; 2.11] | 0.91 |
Echocardiography | ||
 LV ejection fraction (%) | 1.03 [0.98; 1.08] | 0.20 |
 Transmitral peak E velocity max (m/s) | 1.01 [1.00; 1.02] | 0.025 |
 E/e’ septal ratio | 1.02 [0.98; 1.06] | 0.42 |
 RV/RA gradient (mmHg) | 1.01 [0.98; 1.04] | 0.60 |
 RA volume index (ml/m2) | 1.00 [0.99; 1.02] | 0.53 |
 RV fractional area change (%) | 2.01 [0.06; 73.25] | 0.70 |
 TAPSE (mm) | 0.94 [0.89; 1.00] | 0.064 |
Cardiac MR | ||
 LVM index (g/m2) | 0.99 [0.98; 1.01] | 0.62 |
 LV EDV index (ml/m2) | 0.99 [0.98; 1.01] | 0.58 |
 LVEF (%) | 1.03 [0.99; 1.07] | 0.19 |
 RV EDV index (ml/m2) | 1.00 [0.99; 1.01] | 0.59 |
 RVEF (%) | 0.99 [0.96; 1.04] | 0.81 |
 LV mass/volume ratio | 1.24 [0.06; 25.3] | 0.89 |
 LA volume index (ml/m2) | 1.00 [0.98; 1.02] | 0.87 |
 Myocardium native T1 (ms) | 1.01 [0.99; 1.01] | 0.23 |
 ECV (%) | 1.07 [1.01; 1.12] | 0.015 |
 ECV ≥ 33% | 2.62 [1.35; 5.09] | 0.005 |
 LGE (%) | 1.08 [0.96; 1.21] | 0.22 |