Table 1 Population characteristics
Characteristics | AL (n = 24) | ATTR (n = 20) | Healthy subjects (n = 40) | p* |
|---|---|---|---|---|
Clinical | ||||
Age (years) | 65 ± 12 | 73 ± 15 | 40 ± 12 | 0.04$ |
Male (%) | 14 (58) | 17 (85) | 20 (50) | 0.04 |
BMI (kg/m2) | 24.7 ± 3 | 24.5 ± 4 | 22.1 ± 3 | 0.2 |
Diabetes | 2 | 5 | – | 0.1 |
NYHA(I/II/III/IV) | 3/9/9/3 | 2/8/9/1 | – | 0.6 |
Hypertension | 9 | 13 | – | 0.1 |
Hyperlipidemia | 9 | 9 | – | 0.9 |
NT-pro BNP (pg/mL) | 6317 (340–18,908) | 2384 (542–9129) | – | 0.3 |
Troponin T (pg/mL) | 52 (14–112) | 38 (8–54) | – | 0.5 |
Creatinine (μmol/L) | 110 (78–275) | 101 (89–167) | 63 (55–77) | 0.6$ |
Echocardiography | ||||
Septal thickness (mm) | 17 ± 5 | 18 ± 9 | 8 ± 4 | 0.4$ |
LVEF (%) | 57 ± 15 | 50 ± 16 | 66 ± 15 | 0.2$ |
Transmitral E/A | 3.6 ± 8 | 2.6 ± 8 | – | 0.2 |
E/E’ | 16.3 ± 8 | 15.5 ± 8 | – | 0.9 |
GLS (−%) | 12 (6–17) | 9 (8–15) | 18 (15–22) | 0.8$ |