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Fig. 3 | Journal of Cardiovascular Magnetic Resonance

Fig. 3

From: Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation

Fig. 3

Results from Monte Carlo simulations (n = 10,000) on the effects on goodness-of-fit (r2) and plasma volume standard deviation (\( {\sigma}_{V_{plasma}}\Big) \) as a function of increasing the number of samples from 26 min (Protocol 2) (a, b) and increasing the time of the ‘anchor’ point from 30 min (Protocol 3) (c, d). Shaded regions correspond to the standard deviation of the goodness-of-fit (r2), and the points selected for in vivo analysis have been marked a red arrow. Dotted lines correspond to a 3, 2 and 1% plasma volume standard deviation in b, d and f respectively. Simulations of a potential ‘human protocol’ with an increasing number of acute post-contrast sampling (e, f) reveal that measurements as early as 6 min (red arrow) yield an approximate 1% standard deviation in plasma volume

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