Table 2 Comparison of measuring blood volume (Vblood) with reduced ferumoxytol doses (N = 1, for each dose) in mg/kg of iron (Fe), and percentage of the typical dose used in this study (N = 12). Smaller doses resulted in a reduced change in post-contrast LV T1, and a shorter ferumoxytol half-life, but did not produce a significantly different normalized blood volume (p = 0.95, Mann-Whitney U), and except for the 50% dose, the percentage differences from the blood volumes for each subject were within the calculated repeatability coefficient (14%)
| Conc. Fe (mg/kg) | ΔT1 (%) | Half-life (hr) | Vblood (mL/kg) | %ΔVblood |
|---|---|---|---|---|
| 0.69 ± 0.01 | −85.5 ± 0.7 | 3.43 ± 0.49 | 88.1 ± 9.4 | – |
| 0.30 (50%) | − 74.6 | 2.55 | 79.9 | −17.5 |
| 0.23 (20%) | − 65.9 | 2.93 | 95.4 | 12.1 |
| 0.13 (10%) | −53.9 | 2.51 | 86.2 | −5.7 |
