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Table 2 Comparison of measuring blood volume (Vblood) with reduced ferumoxytol doses (N = 1, for each dose) in mg/kg of iron (Fe), and percentage of the typical dose used in this study (N = 12). Smaller doses resulted in a reduced change in post-contrast LV T1, and a shorter ferumoxytol half-life, but did not produce a significantly different normalized blood volume (p = 0.95, Mann-Whitney U), and except for the 50% dose, the percentage differences from the blood volumes for each subject were within the calculated repeatability coefficient (14%)

From: Blood volume measurement using cardiovascular magnetic resonance and ferumoxytol: preclinical validation

Conc. Fe (mg/kg) ΔT1 (%) Half-life (hr) Vblood (mL/kg) Vblood
0.69 ± 0.01 −85.5 ± 0.7 3.43 ± 0.49 88.1 ± 9.4
0.30 (50%) − 74.6 2.55 79.9 −17.5
0.23 (20%) − 65.9 2.93 95.4 12.1
0.13 (10%) −53.9 2.51 86.2 −5.7