Fig. 1

Patient flowchart. Patients were grouped for statistical analysis as indicated. Patients with pulmonary hypertension were compared to two control groups. Patients with left heart disease (LHD), pulmonary arterial hypertension (PAH), PAH due to lung disease and/or hypoxia (PH-lung), chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary hypertension with unclear or multifactorial causes (PH-misc) were compared using ANOVA. Patients with idiopathic pulmonary arterial hypertension (IPAH), connective tissue disease (CTD), congenital heart disease (CHD) and other types of PAH were compared using ANOVA. Patients with PAH were assessed for independent prognostic value of T1. Three patients had previous right heart catheter data showing mean PAP > 25 mmHg but did not have a final diagnosis, and were included in analysis of pulmonary hypertension patients