Late effects of pediatric hematopoietic stem cell transplantation on left ventricular function, aortic stiffness and myocardial tissue characteristics

Table 4 CMR parameters

	Pediatric HSCT recipients (n = 16)	Healthy controls (n = 16)	P value
LV mass and dimensions
Mass, g	95 ± 18	108 ± 23	0.078
Mass/BSA, g/m²	53 ± 9	57 ± 10	0.328
End-diastolic volume, mL	155 ± 29	176 ± 30	0.052
End-diastolic volume/BSA, mL/m²	87 ± 14	93 ± 13	0.238
Mass/end-diastolic volume, g/mL	0.62 ± 0.10	0.61 ± 0.08	0.867
LV systolic function
Stroke volume, mL	83 ± 15	101 ± 17	0.003*
Cardiac output, L	5.2 ± 1.0	6.5 ± 1.0	0.001*
Cardiac index, L/m²	2.9 ± 0.6	3.4 ± 0.5	0.021*
Ejection fraction, %	54 ± 6	58 ± 5	0.055
Global longitudinal strain, %	−20.7 ± 3.5	−22.9 ± 3.0	0.063
Global circumferential strain, %	−23.2 ± 3.6	−23.9 ± 3.5	0.587
Longitudinal peak systolic strain rate, 1/s	−0.95 ± 0.20	−1.06 ± 0.21	0.137
Circumferential peak systolic strain rate, 1/s	−1.21 ± 0.22	−1.32 ± 0.36	0.216
LV diastolic function
E/A ratio	2.76 ± 0.92	2.97 ± 0.91	0.599‡
Estimated LV filling pressure	9.92 ± 3.42	7.24 ± 2.29	0.004‡
Longitudinal early diastolic strain rate, 1/s	1.01 ± 0.26	1.15 ± 0.35	0.224
Circumferential early diastolic strain rate, 1/s	1.28 ± 0.29	1.38 ± 0.35	0.396
LV myocardial tissue characteristics
Myocardial triglyceride content, %	0.47 ± 0.18	0.50 ± 0.13	0.202‡
Native T1 relaxation time, ms	1211 ± 36	1227 ± 28	0.158
Aortic stiffness
Aortic pulse wave velocity, m/s	4.40 ± 0.26	4.29 ± 0.29	0.288

Values are presented as means ± standard deviations. *P < 0.05. ‡P value not based on the Student’s t-test but on the Mann-Whitney U test. HSCT hematopoietic stem cell transplantation, LV left ventricle, BSA body surface area, E/A ratio ratio of early and late peak filling rate. Estimated LV filling pressure: ratio of transmitral early peak velocity and early diastolic mitral septal tissue velocity (E/Ea)

ISSN: 1532-429X