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Table 4 CMR parameters

From: Late effects of pediatric hematopoietic stem cell transplantation on left ventricular function, aortic stiffness and myocardial tissue characteristics

  Pediatric HSCT recipients (n = 16) Healthy controls (n = 16) P value
LV mass and dimensions
 Mass, g 95 ± 18 108 ± 23 0.078
 Mass/BSA, g/m2 53 ± 9 57 ± 10 0.328
 End-diastolic volume, mL 155 ± 29 176 ± 30 0.052
 End-diastolic volume/BSA, mL/m2 87 ± 14 93 ± 13 0.238
 Mass/end-diastolic volume, g/mL 0.62 ± 0.10 0.61 ± 0.08 0.867
LV systolic function
 Stroke volume, mL 83 ± 15 101 ± 17 0.003*
 Cardiac output, L 5.2 ± 1.0 6.5 ± 1.0 0.001*
 Cardiac index, L/m2 2.9 ± 0.6 3.4 ± 0.5 0.021*
 Ejection fraction, % 54 ± 6 58 ± 5 0.055
 Global longitudinal strain, % −20.7 ± 3.5 −22.9 ± 3.0 0.063
 Global circumferential strain, % −23.2 ± 3.6 −23.9 ± 3.5 0.587
 Longitudinal peak systolic strain rate, 1/s −0.95 ± 0.20 −1.06 ± 0.21 0.137
 Circumferential peak systolic strain rate, 1/s −1.21 ± 0.22 −1.32 ± 0.36 0.216
LV diastolic function
 E/A ratio 2.76 ± 0.92 2.97 ± 0.91 0.599‡
 Estimated LV filling pressure 9.92 ± 3.42 7.24 ± 2.29 0.004‡
 Longitudinal early diastolic strain rate, 1/s 1.01 ± 0.26 1.15 ± 0.35 0.224
 Circumferential early diastolic strain rate, 1/s 1.28 ± 0.29 1.38 ± 0.35 0.396
LV myocardial tissue characteristics
 Myocardial triglyceride content, % 0.47 ± 0.18 0.50 ± 0.13 0.202‡
 Native T1 relaxation time, ms 1211 ± 36 1227 ± 28 0.158
Aortic stiffness
 Aortic pulse wave velocity, m/s 4.40 ± 0.26 4.29 ± 0.29 0.288
  1. Values are presented as means ± standard deviations. *P < 0.05. ‡P value not based on the Student’s t-test but on the Mann-Whitney U test. HSCT hematopoietic stem cell transplantation, LV left ventricle, BSA body surface area, E/A ratio ratio of early and late peak filling rate. Estimated LV filling pressure: ratio of transmitral early peak velocity and early diastolic mitral septal tissue velocity (E/Ea)