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Table 2 Ten-fold cross-validation results from penalized logistic regression models using the first 50 PCA modes (PCA50) and from the reference baseline mass/volumes (MassVol) measurement models

From: Right ventricular shape and function: cardiovascular magnetic resonance reference morphology and biventricular risk factor morphometrics in UK Biobank

Factor Model AUC Sensitivity Specificity Precision F1-score npv Cutoff
Cholesterol MassVol 0.587 0.704 0.451 0.346 0.464 0.787 0.495
PCA50* 0.751 0.792 0.579 0.437 0.564 0.871 0.485
Smoking MassVol 0.594 0.856 0.287 0.334 0.480 0.826 0.490
PCA50* 0.699 0.525 0.795 0.517 0.521 0.800 0.511
Diabetes MassVol 0.652 0.740 0.554 0.342 0.468 0.872 0.494
PCA50* 0.817 0.704 0.781 0.502 0.586 0.894 0.504
Previous MI MassVol 0.733 0.699 0.663 0.235 0.351 0.937 0.490
PCA50* 0.853 0.677 0.911 0.529 0.594 0.950 0.518
Angina MassVol 0.671 0.700 0.637 0.196 0.307 0.944 0.497
PCA50* 0.773 0.663 0.763 0.262 0.376 0.947 0.493
Obesity MassVol 0.682 0.675 0.598 0.638 0.656 0.637 0.494
PCA50* 0.839 0.760 0.763 0.771 0.766 0.752 0.500
Hypertension MassVol 0.651 0.693 0.543 0.718 0.705 0.514 0.495
PCA50* 0.770 0.752 0.663 0.789 0.770 0.615 0.494
  1. Statistical tests were performed between MassVol and PCA50. Significant differences (p < 0.005) are represented with an asterisk
  2. PCA principal component analysis, MI myocardial infarction