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Fig. 3 | Journal of Cardiovascular Magnetic Resonance

Fig. 3

From: Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study

Fig. 3

Regional association plot constructed from LocusZoom for the 48 HIF1α variants, based on the 1000 Genomes European population (Nov 2014). Each point represents one of the 48 HIF1α variants. The r2 represents the linkage disequilibrium (i.e., correlation) between each variant and rs11549465. For example, the linkage disequilibrium between the two variants shaded in red and rs11549465 ranges from 0.80 to 1.0. These three variants reflect a unique signal. The linkage disequilibrium between variants shaded in yellow and rs11549465 ranges from 0.60 to 0.80. The variants shaded in yellow reflect another unique signal. Square: variants that were in Jeewa et al.’s study and significant in our study (purple square = rs11549465, yellow square = rs2057482); Triangle: variant analyzed in Jeewa et al.’s study but not significant in our study (green triangle = rs10873142); Diamond: variants significant in this study (left red diamond = rs76308410, yellow diamond = rs7161527, right red diamond = rs74481028, yellow diamond (underneath rs74481028): rs10147275; Circles: variants analyzed in our study but were not significant

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