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Table 1 Characteristics of study cohort

From: Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study

Characteristic

First CMR (N = 237)

Second CMR (N = 92)

N

%

N

%

Gender

 Male

157

66.2

68

73.9

 Female

80

33.8

24

26.1

Race/Ethnicity

 White

182

77.5

68

73.9

 African American

23

9.8

10

10.9

 Hispanic

13

5.5

5

5.4

 Other

17

7.2

9

9.8

 Missing

2

0

Body Mass Index (kg/m2)

 Underweight (< 18.5)

51

21.5

23

25.0

 Normal (18.5 to < 25)

125

52.7

51

55.4

 Overweight (25 to < 30)

34

14.4

9

9.8

 Obese (≥30)

27

11.4

9

9.8

Prematurity

 Yes

40

18.4

22

26.8

 No

177

81.6

60

73.2

 Missing

20

10

Pulmonary Valve Anatomy

 Absent

18

7.9

7

7.8

 Atresia

43

18.8

20

22.2

 Stenosis

168

73.4

63

70.0

 Missing

8

2

RVOT Obstruction

 Yes

18

8.1

10

11.0

 No

203

91.9

81

89.0

 Missing

16

1

Palliative Procedure

 Yes

37

15.6

18

19.6

 No

200

84.4

74

80.4

Age at complete repair (months)

 0–4

149

63.1

52

56.5

 5–8

49

20.8

20

21.7

 9–12

22

9.3

11

12.0

  > 12

16

6.8

9

9.8

 Missing

1

0

Type of Surgical Repair

 Transannular Patch

176

75.2

71

77.2

 Right Ventricle to Pulmonary Artery Conduit

35

15.0

13

14.1

 Nontransannular Patch or Ventricular Septal Defect Closure Only

23

9.8

8

8.7

 Missing

3

0

Intervening events since complete repair

 Yes

120

50.6

56

60.9

 No

117

49.4

36

39.1

Pulmonary Artery Confluence

 Yes

217

93.1

87

95.6

 No

16

6.9

4

4.4

 Missing

14

1

Pulmonary Regurgitant Fraction

 Mild (0–20)

53

23.0

0

0

 Moderate (> 20–40)

90

39.1

37

50.0

 Severe (> 40)

87

37.8

37

50.0

 Missing

7

18

 

Median

IQR

Median

IQR

Age (years)

12.3

8.7–16.2

15.8

12.2–18.7

Time between complete repair and first CMR (years)

11.0

8–15

15.0

11–18

RV fibrotic volume, indexed (ml/m2)

0.6

0.3–1.0

0.7

0.4–1.0

RV fibrotic score

2

1–3

2

1–3

RVEDVI

112.0

89.7–140.0

125.9

105.5–144.6

RVEF (%)

58.8

52.8–63.8

56.6

50.5–60.9

  1. CMR cardiovascular magnetic resonance, IQR interquartile range, RV right ventricular, RVEDVI indexed right ventricular end-diastolic volume, RVEF right ventricular ejection fraction, RVOT right ventricular outflow tract