Fig. 4

T2* and delta R2* of the myocardium The representative mapping images (a) and graphs (b) compare the pre- and post-contrast (6 h and 24 h) T2* and delta R2* of LV between the control, day 14, and day 21 groups. The images were obtained from the same rats used in Fig. 3. The day 21 images are magnified to highlight the region with especially high T2* (septum and RV), which showed less ferumoxytol accumulation on 6 h-FE-CMR but high gadolinium accumulation on EGE and LGE (c). Histologically, this region corresponded with myocardial necrosis (right panel, arrows). The scatter plot (d) shows a positive linear correlation between the necrotic area size (%LV) and pre-contrast T2* of LV (r = 0.86, p < 0.001). [statistical analysis; * p = 0.01, †p < 0.01, ‡p < 0.001, compared to Control]