| Mean ± SD or n (%) | Pa | Pb | |||
---|---|---|---|---|---|---|
Subjects with moderate to heavy alcohol consumption | Healthy controls (n = 35) | |||||
All (n = 34) | Heavy consumption (n = 19) | Moderate consumption (n = 15) | ||||
Age, years | 48.8 ± 9.1 | 49.9 ± 11.1 | 47.4 ± 5.9 | 49.5 ± 9.7 | 0.771 | 0.407 |
BMI, kg/m2 | 26.0 ± 2.9 | 25.8 ± 3.1 | 26.3 ± 2.8 | 23.2 ± 2.2 | < 0.001 | 0.672 |
Smoke | 21 (62.0) | 12 (63.2) | 9 (60.0) | 7 (20.0) | < 0.001 | 0.856 |
SBP, mmHg | 120.0 ± 11.2 | 116.8 ± 11.4 | 124.1 ± 9.8 | 116.5 ± 10.8 | 0.192 | 0.055 |
DBP, mmHg | 77.6 ± 8.3 | 76.5 ± 8.3 | 78.9 ± 8.5 | 73.2 ± 6.7 | 0.020 | 0.424 |
Alcohol consumption | ||||||
 Duration, years | 26.2 ± 8.9 | 26.5 ± 10.7 | 25.8 ± 6.3 | 0 | – | 0.806 |
 Dose, g/day | 115.8 ± 119.7 | 167.2 ± 140.6 | 50.5 ± 13.2 | 0 | – | 0.002 |
Left ventricle | ||||||
 LVEDV, mL | 116.2 ± 21.5 | 115.4 ± 25.4 | 117.2 ± 16.0 | 106.0 ± 20.2 | 0.046 | 0.808 |
 LVESV, mL | 41.7 ± 12.2 | 43.2 ± 13.5 | 39.8 ± 10.5 | 35.3 ± 7.6 | 0.010 | 0.425 |
 LVSV, mL | 74.4 ± 17.7 | 72.1 ± 18.5 | 77.4 ± 16.7 | 70.7 ± 16.7 | 0.369 | 0.396 |
 LVEF, % | 64.9 ± 6.7 | 63.8 ± 6.1 | 66.3 ± 7.3 | 66.8 ± 5.6 | 0.219 | 0.282 |
 CO, L/min | 5.0 ± 1.0 | 4.9 ± 1.2 | 5.2 ± 0.8 | 4.6 ± 1.0 | 0.073 | 0.312 |
 LV mass, g | 112.1 ± 19.5 | 110.7 ± 22.7 | 113.9 ± 15.2 | 105.7 ± 17.5 | 0.158 | 0.646 |
Right ventricle | ||||||
 RVEDV, mL | 130.3 ± 24.5 | 130.5 ± 25.7 | 130.0 ± 23.7 | 117.5 ± 26.3 | 0.041 | 0.954 |
 RVESV, mL | 64.3 ± 15.0 | 62.8 ± 12.9 | 65.5 ± 16.6 | 54.6 ± 13.2 | 0.006 | 0.610 |
 RVSV, mL | 66.0 ± 14.9 | 67.3 ± 18.1 | 65.0 ± 12.3 | 63.0 ± 18.7 | 0.458 | 0.686 |
 RVEF, % | 50.7 ± 6.8 | 51.3 ± 8.3 | 50.2 ± 5.4 | 52.9 ± 8.9 | 0.251 | 0.654 |