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Table 1 Baseline characteristics of IIM patients compared with those of normal controls

From: Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in myocardial and skeletal muscles in idiopathic inflammatory cardiomyopathy

Characteristics (units)IIM patients (n = 44)Healthy Controls (n = 30)P value
Age (years)49.0 ± 12.048.2 ± 15.60.232
Males, n (%)22 (50.0%)15 (50.0%)1.000
BMI (kg/m2)22.4 ± 3.022.8 ± 2.80.465
Systolic blood pressure, mmHg122 ± 14121 ± 110.673
Diastolic blood pressure, mmHg78 ± 872 ± 50.512
Heart rate76.5 ± 9.774.1 ± 7.20.592
Disease duration (years)0.5 (0.2, 2.0)
Clinical presentation
 Proximal muscle weakness, n (%)41 (93.2%)
 Rash, n (%)29 (65.9%)
 Myalgia, n (%)23 (52.3%)
 Dysphagia, n (%)17 (38.6%)
Comorbidity
 Hypertension, n (%)6 (13.6%)
 Diabetes, n (%)1 (2.3%)
Biomarkers
 Hct0.40 ± 0.050.43 ± 0.030.003
 CRP (mg/L)4.3 (1.7–9.7)
 ESR (mm/h)28 (23–47)
 CK (U/L)316 (79–2202)
 CK-MB (ng/mL)20.6 (5.3–54.0)
 cTnT (g/L)96 (40–269)
 NT-proBNP (pg/mL)226 (85–747)
Medication
 Steroids, n (%)44 (100%)
 Methotrexate, n (%)22 (50.0%)
 Cyclophosphamide, n (%)12 (27.3%)
 Chloroquine, n (%)18 (40.9%)
 Azathioprine, n (%)4 (9.1%)
Cardiac structure and function
 LVEDVi, mL/m282.7 ± 26.677.1 ± 13.30.300
 LVESVi, mL/m233.9 ± 25.129.1 ± 8.10.428
 LVEF (%)61.4 ± 11.862.0 ± 5.20.958
 LVmassi (g/m2)50.8 ± 15.043.6 ± 8.20.037
 RVEDVi, mL/m280.9 ± 22.268.7 ± 18.50.042
 RVESVi, mL/m238.2 ± 17.134. 3 ± 10.50.146
 RVEF (%)53.6 ± 9.857.2 ± 5.20.055
Myocardial tissue characterization
 T2w ratio1.3 ± 0.41.2 ± 0.40.259
 LGE, n (%)11 (25%)0
 LGE extent, %12.0 ± 3.10
 Native T1 mapping-myocardial, ms1275 ± 821199 ± 47< 0.001
 T2 mapping-myocardial, ms44.2 ± 4.038.3 ± 2.9< 0.001
 ECV-myocardial, %32.3 ± 6.226.6 ± 2.4< 0.001
Skeletal tissue characterization
 Native T1 mapping-skeletal, ms1287 ± 1491107 ± 70< 0.001
 T2 mapping-skeletal, ms34.4 ± 3.126.0 ± 1.4< 0.001
 ECV-skeletal, %31.1 ± 12.813.6 ± 3.1< 0.001
  1. Abbreviations: BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, NYHA New York Heart Association functional classification, Hct hematocrit, CRP C-reactive protein, ESR erythrocyte sedimentation rate, CK creatine kinase, CK-MB creatine kinase-MB, TnT Troponins T, NT-proBNP N-terminal pro b-type natriuretic peptide, LVEDVi left ventricular end-diastolic volume index, LVESVi left ventricular end-systolic volume index, LVmassi left ventricular mass index, LVEF left ventricular ejection fraction, RVEDVi right ventricular end-diastolic volume index, RVESVi right ventricular end-systolic volume index, RVEF right ventricular ejection fraction, T2W T2-weighted ratio, LGE late gadolinium enhancement, ECV extracellular volume fraction
  2. Values in bold indicate P values < 0.05
  3. P values for comparison between IIM patients and normal controls