Characteristics (units) | IIM patients (n = 44) | Healthy Controls (n = 30) | P value |
---|---|---|---|
Age (years) | 49.0 ± 12.0 | 48.2 ± 15.6 | 0.232 |
Males, n (%) | 22 (50.0%) | 15 (50.0%) | 1.000 |
BMI (kg/m2) | 22.4 ± 3.0 | 22.8 ± 2.8 | 0.465 |
Systolic blood pressure, mmHg | 122 ± 14 | 121 ± 11 | 0.673 |
Diastolic blood pressure, mmHg | 78 ± 8 | 72 ± 5 | 0.512 |
Heart rate | 76.5 ± 9.7 | 74.1 ± 7.2 | 0.592 |
Disease duration (years) | 0.5 (0.2, 2.0) | – | – |
Clinical presentation | |||
 Proximal muscle weakness, n (%) | 41 (93.2%) | – | – |
 Rash, n (%) | 29 (65.9%) | – | – |
 Myalgia, n (%) | 23 (52.3%) | – | – |
 Dysphagia, n (%) | 17 (38.6%) | – | – |
Comorbidity | |||
 Hypertension, n (%) | 6 (13.6%) | – | – |
 Diabetes, n (%) | 1 (2.3%) | – | – |
Biomarkers | |||
 Hct | 0.40 ± 0.05 | 0.43 ± 0.03 | 0.003 |
 CRP (mg/L) | 4.3 (1.7–9.7) | – | – |
 ESR (mm/h) | 28 (23–47) | – | – |
 CK (U/L) | 316 (79–2202) | – | – |
 CK-MB (ng/mL) | 20.6 (5.3–54.0) | – | – |
 cTnT (g/L) | 96 (40–269) | – | – |
 NT-proBNP (pg/mL) | 226 (85–747) | – | – |
Medication | |||
 Steroids, n (%) | 44 (100%) | – | – |
 Methotrexate, n (%) | 22 (50.0%) | – | – |
 Cyclophosphamide, n (%) | 12 (27.3%) | – | – |
 Chloroquine, n (%) | 18 (40.9%) | – | – |
 Azathioprine, n (%) | 4 (9.1%) | – | – |
Cardiac structure and function | |||
 LVEDVi, mL/m2 | 82.7 ± 26.6 | 77.1 ± 13.3 | 0.300 |
 LVESVi, mL/m2 | 33.9 ± 25.1 | 29.1 ± 8.1 | 0.428 |
 LVEF (%) | 61.4 ± 11.8 | 62.0 ± 5.2 | 0.958 |
 LVmassi (g/m2) | 50.8 ± 15.0 | 43.6 ± 8.2 | 0.037 |
 RVEDVi, mL/m2 | 80.9 ± 22.2 | 68.7 ± 18.5 | 0.042 |
 RVESVi, mL/m2 | 38.2 ± 17.1 | 34. 3 ± 10.5 | 0.146 |
 RVEF (%) | 53.6 ± 9.8 | 57.2 ± 5.2 | 0.055 |
Myocardial tissue characterization | |||
 T2w ratio | 1.3 ± 0.4 | 1.2 ± 0.4 | 0.259 |
 LGE, n (%) | 11 (25%) | 0 | – |
 LGE extent, % | 12.0 ± 3.1 | 0 | – |
 Native T1 mapping-myocardial, ms | 1275 ± 82 | 1199 ± 47 | < 0.001 |
 T2 mapping-myocardial, ms | 44.2 ± 4.0 | 38.3 ± 2.9 | < 0.001 |
 ECV-myocardial, % | 32.3 ± 6.2 | 26.6 ± 2.4 | < 0.001 |
Skeletal tissue characterization | |||
 Native T1 mapping-skeletal, ms | 1287 ± 149 | 1107 ± 70 | < 0.001 |
 T2 mapping-skeletal, ms | 34.4 ± 3.1 | 26.0 ± 1.4 | < 0.001 |
 ECV-skeletal, % | 31.1 ± 12.8 | 13.6 ± 3.1 | < 0.001 |