Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in myocardial and skeletal muscles in idiopathic inflammatory cardiomyopathy

Table 3 Clinical biomarkers and CMR parameters at baseline and follow-up among IIM patients with CMR follow-up

	Baseline (n = 28)	Follow-up (n = 28)	P^* value
Biomarker
Hct	0.40 ± 0.05	0.43 ± 0.04	0.005
CRP (mg/L)	5.7 (2.8–17.9)	2.2 (1.8–4.1)	0.024
ESR (mm/h)	26 (23–47)	22 (5–33)	0.064
CK (U/L)	479 (83–1060)	106 (75–148)	0.038
CK-MB (ng/mL)	24.7 (7.1–74.6)	2.5 (1.0–4.8)	< 0.001
cTnT (g/L)	102 (60–480)	17 (10–67)	< 0.001
BNP (pg/mL)	235 (72–1184)	50 (26–109)	0.007
Structural and function
LVEDVi, ml³/m²	83.7 ± 19.4	82.3 ± 18.0	0.703
LVESVi, ml³/m²	34.0 ± 15.3	34.3 ± 13.8	0.549
LVmassi, g/m²	51.2 ± 12.5	45.2 ± 10.2	0.011
LVEF, %	59.4 ± 8.7	60.5 ± 10.5	0.395
RVEDVi, ml³/m²	81.8 ± 16.2	79.8 ± 11.6	0.279
RVESVi, ml³/m²	39.3 ± 11.8	37.4 ± 8.0	0.073
RVEF, %	53.2 ± 6.2	55.2 ± 6.8	0.492
Myocardial tissue characteristics
T2w ratio	1.3 ± 0.5	1.3 ± 0.4	0.621
LGE presence, n(%)	7 (25%)	7 (25%)	1
LGE extent, %	11.8 ± 2.9	8.1 ± 2.0	0.239
Native T1-myo, ms	1289 ± 53	1262 ± 59	0.013
T2 mapping-myo, ms	44.4 ± 4.0	41.8 ± 4.2	0.001
ECV-myo, %	30.7 ± 4.1	27.6 ± 4.4	0.001
Skeletal tissue characteristics
Native T1-sk, ms	1268 ± 103	1154 ± 73	< 0.001
T2 mapping-sk, ms	34.5 ± 3.5	29.7 ± 2.8	< 0.001
ECV-sk, %	29.2 ± 11.1	21.9 ± 11.2	0.011

Abbreviations: Hct hematocrit, CRP C-reactive protein, ESR erythrocyte sedimentation rate, CK creatine kinase, CK-MB creatine kinase-MB, TnT troponin T, NT-proBNP N-terminal pro b-type natriuretic peptide, LVEDVi left ventricular end-diastolic volume index, LVESVi left ventricular end-systolic volume index, LVmassi left ventricular mass index, LVEF left ventricular ejection fraction, RVEDVi right ventricular end-diastolic volume index, RVESVi right ventricular end-systolic volume index, RVEF right ventricular ejection fraction, T2W T2-weighted ratio, LGE late gadolinium enhancement, ECV extracellular volume fraction
Values in bold indicate P values < 0.05
P^* value for comparison between baseline and follow-up characteristics among IIM patients

ISSN: 1532-429X