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Table 1 Summary of the study characteristics

From: Cardiac structural changes after transcatheter aortic valve replacement: systematic review and meta-analysis of cardiovascular magnetic resonance studies

Study, Year Summary Number of patients with pre- and post-TAVR CMR Follow-up (months) Age Male (%) Diabetes
n (%)
Previous MI
n (%)
Baseline LVEF (%) LVEF (%) at Late Follow-up Valve Prosthesis Early post-TAVR CMR findings (within 7 days post-TAVR) Excluded patients, Explanation
Gastl M, et al. 2018 [25] 43 patients with severe AS underwent TAVR. 29 6 81.9 ± 4.9 43% 12 (28) 5 (12) 58.1 ± 16.1 62.9 ± 10.4 CoreValve, Edwards Sapien 14 patients (poor image quality, left bundle branch block)
aMusa TA, et al. 2018 [10] 59 patients with severe AS underwent TAVR with either CoreValve (n = 27) or Lotus (n = 32). 19 6 79.6 ± 6.3 63% 2 (11) 3 (16) 56.2 ± 12.8 56.4 ± 8.6 CoreValve CMR findings at median 4 days:
No significant changes to LVEDVi and LVEF (p = 0.46 and p = 0.84)
Significant reduction of LVMi (75.4 ± 15.0 vs. 65.8 ± 13.6 g/m2, p < 0.001)
15 patients (Death, PPM, withdrawal)
25 6 78.6 ± 8.7 56% 5 (20) 6 (24) 51.0 ± 19.0 54.1 ± 9.3 Lotus No significant changes to LVEDVi and LVEF (p = 0.55 and p = 0.49)
No significant changes to LVMi (70.8 ± 25.0 vs 69.6 ± 16.2 g/m2, p = 0.81)
Dobson LE, et al. 2017 [9] 88 patients with severe AS underwent TAVR. Ultimately, 24 patients with new left bundle branch block who were matched with 24 patients with a narrow post-procedure QRS were assessed. 24 6 79.6 ± 9.6 54% 2 (8.3) 2 (8.3) 56.6 ± 10.5 54.4 ± 9.3 CoreValve, Lotus 40 patients were excluded for various reasons, (Death, PPM, withdrawal, right bundle branch block, post-procedural myocardial infarction in 23 patients; and an additional 17 because they were not matched to a control group. CMR results of those patients were not presented)
24 6 80.5 ± 6.2 54% 5 (20.8) 5 (20.8) 54.1 ± 11.5 58.7 ± 9
Nucifora G, et al. 2017 [26] 59 patients with severe AS underwent either TAVR (n = 35) or SAVR (n = 24). For the current manuscript, only the TAVR cohort was considered. 17 15 ± 4 85 ± 6 63% NA 68 ± 16 70 ± 14 Edwards Sapien XT CMR findings at 4.7 ± 4 days:
No significant changes to LVEF, and LVMi (p = 0.63 and p = 0.27)
18 patients (not mentioned)
aMusa TA, et al. 2016 [11] 167 patients with severe AS underwent TAVR (n = 101), or SAVR (n = 66). For the current manuscript, only the TAVR cohort was considered. 56 6 80.4 ± 6.6 57% 11 (20) 11 (20) 52 ± 13 53 ± 11 CoreValve, Lotus 45 patients (Death, PPM, withdrawal, valvuloplasty, medical therapy, claustrophobia)
Fairbairn TA, et al.2013 [27] 77 patients with severe AS underwent TAVR (n = 50) or SAVR (n = 27). For the current manuscript, only the TAVR cohort was considered. 25 6 80 ± 6 56% 7 (28) 5 (20) 52 ± 12 56 ± 10 CoreValve 25 patients (Death, PPM, withdrawal, valvuloplasty, medical therapy, claustrophobia)
La Manna A, et al. 2013 [28] 39 patients with severe AS underwent TAVR 27 6 80.7 ± 5.2 37% 4 (14.8) 7 (25.9) 61.5 ± 14.5 65.1 ± 7.2 CoreValve, Edwards-Sapien 12 patients (Death, PPM, withdrawal)
Uddin A, et al. 2013 (abstract) [24] 25 patients with severe AS had TAVR and underwent CMR. 25 6 80.6 ± 6.6 56% 52.1 ± 11.8 55.9 ± 9.6 CoreValve
Gruenig S, et al. 2013 (abstract) [30] 20 patients with severe AS underwent TAVR and had CMR. 20 6 83.6 ± 10.5 55 ± 21 63 ± 39 CoreValve,
Edwards-Sapien
Richardson J, et al. 2012 (abstract) [31] 14 patients with severe AS underwent TAVR and had CMR. 14 10 54 ± 4 57 ± 5 CoreValve, Edwards-Sapien
  1. CMR Cardiovascular magnetic resonance, TAVR Transcatheter aortic valve replacement, SAVR Surgical aortic valve replacement, HTN hypertension, MI Myocardial infarction, LVEF Left ventricular ejection fraction, PPM Permanent pacemaker
  2. Please note that not all patients with available baseline characteristics in included studies had follow-up CMR available
  3. aThese 2 publication included 100 patients of whom 7 were repeated