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Table 3 Resting and peak cardiac function

From: Exercise cardiovascular magnetic resonance reveals reduced cardiac reserve in pediatric cancer survivors with impaired cardiopulmonary fitness

  Normal Fitness Impaired Fitness P
Resting Echocardiography
 LVEF, % 55.1 ± 3.6 55.3 ± 8.6 0.97
 LV FS, % 32.9 ± 5.4 30.5 ± 5.0 0.32
 GLS, % −18.6 ± 2.4 − 17.8 ± 2.1 a 0.46
 E/A 1.87 (1.09, 2.65) 1.79 (0.77, 2.81) 0.79
 E/e’ 6.0 (4.4, 7.6) 6.8 (5.1, 8.5) 0.26
 DT, cm/s 183 ± 23 176 ± 64 0.64
Resting CMR
 GLS, % −15.3 ± 2.3 −14.9 ± 2.0 b 0.69
 LVEF, % 53.8 ± 3.8 52.6 ± 6.6 0.66
 RVEF, % 49.4 ± 4.0 55.6 ± 4.8 0.006
 SVI, mL/m2 51 ± 11 43 ± 9 0.09
 CI, L/min/m2 4.0 ± 1.0 3.6 ± 0.6 0.29
Exercise CMR
 LVEFpeak, % 65.0 ± 3.2 60.0 ± 7.8 0.07
 RVEFpeak, % 62.8 ± 5.1 63.9 ± 6.3 0.67
 SVIpeak, mL/m2 60 ± 15 44 ± 9 0.007
 CIpeak, L/min/m2 9.0 ± 1.6 6.8 ± 1.2 0.003
 a-vO2 diffc 16.3 ± 3.3 12.9 ± 2.5 0.016
  1. Values are means ±SD or median (interquartile range). LV Left ventricular, LVEF Left ventricular ejection fraction, FS Fractional shortening, GLS Global longitudinal strain, E/A Ratio of peak early-to-late mitral inflow velocities, E/e’ Ratio of peak mitral inflow to peak early mitral annular velocity, DT Deceleration time, CMR Cardiovascular magnetic resonance imaging, RVEF Right ventricular ejection fraction, SVI Stroke volume index, CI Cardiac index, a-vO2 diff Arterio-venous oxygen difference. a n = 7; b n = 11; c calculated using peak VO2 from cardiopulmonary exercise test and peak cardiac output from exercise CMR