Myocardial fibrosis in asymptomatic and symptomatic chronic severe primary mitral regurgitation and relationship to tissue characterisation and left ventricular function on cardiovascular magnetic resonance

Table 2 Correlation of histological fibrosis against non-invasive pre-operative imaging parameters

	Correlation with CVF_mean			Correlation with ECV
	N	Rho	P-value	N	Rho	P-value
LVEDVI (ml/m²)	86	− 0.02	0.853	101	0.12	0.234
LVESVI (ml/m²)	86	0.07	0.541	101	0.22	0.025
LVMI (g/m²)	86	− 0.12	0.261	101	− 0.05	0.640
LVEF (%)	86	− 0.15	0.178	101	− 0.22	0.029
GCS (%)^b	84	0.14	0.221	99	0.31	0.002
GLS (%)^b	84	0.12	0.271	99	0.29	0.003
LAVI (ml/m²)	84	0.17	0.123	99	0.26	0.008
Echocardiography E/eʹ	72	0.09	0.460	87	0.25	0.022
NTproBNP	84	0.35	0.001	99	0.54	< 0.001
RVESVI (ml/m²)	86	− 0.10	0.381	101	0.21	0.037
RVEF (%)	86	− 0.06	0.579	101	− 0.14	0.170
RV E_ll	86	0.09	0.411	101	0.30	0.003
MR volume (ml)	86	0.04	0.714	101	− 0.07	0.471
MR fraction (%)	86	0.16	0.147	101	0.02	0.868
ECV (%)	83	0.18	0.101	–	–	–
Native T1 (ms)	85	0.04	0.714	101	0.62	< 0.001
LGE presence^a	84	− 0.07	0.514	101	0.06	0.535
PASP (mmHg)	71	0.14	0.232	82	0.14	0.209
Degeneration subtype (Barlow’s)^a	77	0.21	0.070	91	0.13	0.208

Results are from Spearman’s (Rho) correlation coefficients. Italic P-values are significant at P < 0.05
ECV extracellular volume, GCS global circumferential strain, GLS global longitudinal strain, LAVI left atrial volume indexed, LGE late gadolinium enhancement, LVEDVI left ventricular diastolic volume indexed, LVEF left ventricular ejection fraction, LVESVI left ventricular systolic volume indexed, LVMI left ventricular mass indexed, MR mitral regurgitation, NTproBNP N-terminal pro-brain natriuretic peptide, PASP pulmonary artery systolic pressure, RVEF right ventricular ejection fraction, RV E_ll right ventricular longitudinal strain, RVESVI right ventricular end-systolic volume indexed
^aDichotomous variables
^bGCS and GLS are expressed as negative values, therefore a positive correlation between ECV and strain suggests that increased ECV is related with worse (less negative) strain

ISSN: 1532-429X