Parameters | Pre-AVR (n = 41) | Post-AVR (n = 41) | Healthy controls (n = 10) | P value pre-AVR vs post-AVR | P value pre-AVR vs healthy controls | P values post-AVR vs healthy controls |
---|---|---|---|---|---|---|
CMR parameters | ||||||
 Myocardial mass/BSA [mg/m2] | 72 ± 21 | 50 ± 13 | 40 ± 8 | < 0.001 | < 0.001 | 0.019 |
 LVESD [mm] | 34 ± 6 | 32 ± 4 | 34 ± 2 | < 0.001 | 0.943 | 0.035 |
 Myocardial wall thickness end systolic [mm] | 11 ± 2 | 10 ± 2 | 8 ± 1 | < 0.001 | < 0.001 | 0.001 |
 LVEDV/BSA [ml/m2] | 93 ± 22 | 77 ± 13 | 82 ± 9 | < 0.001 | 0.117 | 0.169 |
 LVESV/BSA [ml/m2] | 41 ± 18 | 31 ± 9 | 34 ± 4 | < 0.001 | 0.393 | 0.064 |
 LVEF [%] | 58 ± 10 | 61 ± 7 | 59 ± 3 | 0.027 | 0.462 | 0.088 |
 LV mass-volume-index [g/ml] | 0.8 ± 0.2 | 0.7 ± 0.2 | 0.5 ± 0.1 | 0.001 | < 0.001 | < 0.001 |
 RF [%] | 9 ± 6 | 7 ± 5 | 3 ± 2 | 0.115 | 0.004 | 0.005 |
 Heart rate [bpm] | 67 ± 11 | 70 ± 12 | 62 ± 10 | 0.189 | 0.302 | 0.104 |
 CO_total [l/min] | 6.8 ± 1.9 | 6.3 ± 1.7 | 5.4 ± 1.2 | 0.048 | 0.041 | 0.184 |
 CI [(l/min)/m2] | 3.5 ± 0.8 | 3.2 ± 0.7 | 2.9 ± 0.4 | 0.056 | 0.039 | 0.265 |
 SV_total [ml] | 79 ± 20 | 76 ± 15 | 74 ± 19 | 0.396 | 0.440 | 0.440 |
 ECV midwall [%] | 23 ± 2 | 27 ± 3 |  | < 0.001 | – | – |
 aECV midwall [ml] | 32 ± 11 | 27 ± 9 |  | < 0.001 | – | – |
 aECV/BSA midwall [ml/m2] | 16 ± 5 | 14 ± 4 |  | < 0.001 | – | – |
 GLS [%] | − 21.2 ± 5 | − 24.8 ± 4 |  | < 0.001 | – | – |
 Late gadolinium enhancement, n (%) | 5 (16%) | 8 (23%) | – | 1.000 | – | – |
 Mitral regurgitation II-IV, n (%) | 0 (0%) | 1 (2%) | 0 (0%) | 1.000 | – | 0.618 |
Heart power parameters | ||||||
 LV myocardial power [W/m2] | 8 ± 3 | 5 ± 2 | 5 ± 0.8 | < 0.001 | < 0.001 | 0.924 |
 Circulatory power [W] | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.1 ± 0.3 | 0.462 | 0.097 | 0.462 |
 Circulatory efficiency [%] | 9.3 ± 3 | 13.3 ± 5 | 12.3 ± 2 | < 0.001 | 0.004 | 0.112 |
 Circulatory efficiency improvement [%] | – | 4.1 ± 5.7 | – | – | – | – |
Metabolic parameters | ||||||
 NT-pro-BNP [ng/l] | 770 ± 926 | 334 ± 261 | 113 ± 113 | < 0.001 | < 0.001 | 0.001 |
 Hemoglobin [g/dl] | 14.2 ± 1.3 | 13.5 ± 1.3 | 13.9 ± 0.8 | 0.011 | 0.607 | 0.184 |
 Hematocrit [%] | 42 ± 4 | 42 ± 4 | 41 ± 3 | 0.609 | 0.511 | 0.497 |
Clinical parameters | ||||||
 NYHA III-IV, n(%) | 18 (35%) | 3 (7%) | 0 (0%) | < 0.001 | 0.009 | 0.378 |
 Systolic blood pressure [mmHg] | 137 ± 17 | 138 ± 19 | 136 ± 15 | 0.650 | 0.704 | 0.877 |
 Diastolic blood pressure [mmHg] | 75 ± 10 | 75 ± 9 | 74 ± 9 | 0.872 | 0.868 | 0.831 |
 Mean arterial pressure [mmHg] | 96 ± 11 | 96 ± 11 | 95 ± 9 | 0.948 | 0.803 | 0.822 |
 Mean aortic pressure gradient [mmHg] | 56 ± 15 | 11 ± 5 | 5 ± 3 | < 0.001 | < 0.001 | < 0.001 |
 Maximal aortic pressure gradient [mmHg] | 83 ± 22 | 19 ± 7 | 9.5 ± 5 | < 0.001 | < 0.001 | < 0.001 |
 Pulse pressure [mmHg] | 63 ± 16 | 63 ± 16 | 62 ± 13 | 0.906 | 0.972 | 0.905 |
 6-min walk distance [m] |  | 518 ± 84 | 538 ± 111 | – | – | 0.646 |