CMR parameters
|
Myocardial mass/BSA [mg/m2]
|
72 ± 21
|
50 ± 13
|
40 ± 8
|
< 0.001
|
< 0.001
|
0.019
|
LVESD [mm]
|
34 ± 6
|
32 ± 4
|
34 ± 2
|
< 0.001
|
0.943
|
0.035
|
Myocardial wall thickness end systolic [mm]
|
11 ± 2
|
10 ± 2
|
8 ± 1
|
< 0.001
|
< 0.001
|
0.001
|
LVEDV/BSA [ml/m2]
|
93 ± 22
|
77 ± 13
|
82 ± 9
|
< 0.001
|
0.117
|
0.169
|
LVESV/BSA [ml/m2]
|
41 ± 18
|
31 ± 9
|
34 ± 4
|
< 0.001
|
0.393
|
0.064
|
LVEF [%]
|
58 ± 10
|
61 ± 7
|
59 ± 3
|
0.027
|
0.462
|
0.088
|
LV mass-volume-index [g/ml]
|
0.8 ± 0.2
|
0.7 ± 0.2
|
0.5 ± 0.1
|
0.001
|
< 0.001
|
< 0.001
|
RF [%]
|
9 ± 6
|
7 ± 5
|
3 ± 2
|
0.115
|
0.004
|
0.005
|
Heart rate [bpm]
|
67 ± 11
|
70 ± 12
|
62 ± 10
|
0.189
|
0.302
|
0.104
|
CO_total [l/min]
|
6.8 ± 1.9
|
6.3 ± 1.7
|
5.4 ± 1.2
|
0.048
|
0.041
|
0.184
|
CI [(l/min)/m2]
|
3.5 ± 0.8
|
3.2 ± 0.7
|
2.9 ± 0.4
|
0.056
|
0.039
|
0.265
|
SV_total [ml]
|
79 ± 20
|
76 ± 15
|
74 ± 19
|
0.396
|
0.440
|
0.440
|
ECV midwall [%]
|
23 ± 2
|
27 ± 3
| |
< 0.001
|
–
|
–
|
aECV midwall [ml]
|
32 ± 11
|
27 ± 9
| |
< 0.001
|
–
|
–
|
aECV/BSA midwall [ml/m2]
|
16 ± 5
|
14 ± 4
| |
< 0.001
|
–
|
–
|
GLS [%]
|
− 21.2 ± 5
|
− 24.8 ± 4
| |
< 0.001
|
–
|
–
|
Late gadolinium enhancement, n (%)
|
5 (16%)
|
8 (23%)
|
–
|
1.000
|
–
|
–
|
Mitral regurgitation II-IV, n (%)
|
0 (0%)
|
1 (2%)
|
0 (0%)
|
1.000
|
–
|
0.618
|
Heart power parameters
|
LV myocardial power [W/m2]
|
8 ± 3
|
5 ± 2
|
5 ± 0.8
|
< 0.001
|
< 0.001
|
0.924
|
Circulatory power [W]
|
1.3 ± 0.4
|
1.3 ± 0.4
|
1.1 ± 0.3
|
0.462
|
0.097
|
0.462
|
Circulatory efficiency [%]
|
9.3 ± 3
|
13.3 ± 5
|
12.3 ± 2
|
< 0.001
|
0.004
|
0.112
|
Circulatory efficiency improvement [%]
|
–
|
4.1 ± 5.7
|
–
|
–
|
–
|
–
|
Metabolic parameters
|
NT-pro-BNP [ng/l]
|
770 ± 926
|
334 ± 261
|
113 ± 113
|
< 0.001
|
< 0.001
|
0.001
|
Hemoglobin [g/dl]
|
14.2 ± 1.3
|
13.5 ± 1.3
|
13.9 ± 0.8
|
0.011
|
0.607
|
0.184
|
Hematocrit [%]
|
42 ± 4
|
42 ± 4
|
41 ± 3
|
0.609
|
0.511
|
0.497
|
Clinical parameters
|
NYHA III-IV, n(%)
|
18 (35%)
|
3 (7%)
|
0 (0%)
|
< 0.001
|
0.009
|
0.378
|
Systolic blood pressure [mmHg]
|
137 ± 17
|
138 ± 19
|
136 ± 15
|
0.650
|
0.704
|
0.877
|
Diastolic blood pressure [mmHg]
|
75 ± 10
|
75 ± 9
|
74 ± 9
|
0.872
|
0.868
|
0.831
|
Mean arterial pressure [mmHg]
|
96 ± 11
|
96 ± 11
|
95 ± 9
|
0.948
|
0.803
|
0.822
|
Mean aortic pressure gradient [mmHg]
|
56 ± 15
|
11 ± 5
|
5 ± 3
|
< 0.001
|
< 0.001
|
< 0.001
|
Maximal aortic pressure gradient [mmHg]
|
83 ± 22
|
19 ± 7
|
9.5 ± 5
|
< 0.001
|
< 0.001
|
< 0.001
|
Pulse pressure [mmHg]
|
63 ± 16
|
63 ± 16
|
62 ± 13
|
0.906
|
0.972
|
0.905
|
6-min walk distance [m]
| |
518 ± 84
|
538 ± 111
|
–
|
–
|
0.646
|