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Table 4 Pre- and Post-AVR parameters in patients with and without restored CircE post-AVR

From: Circulatory efficiency in patients with severe aortic valve stenosis before and after aortic valve replacement

  Pre-AVR not restored CircE (n = 10) Post-AVR not restored CircE (n = 10) Pre-AVR restored CircE (n = 31) Post-AVR restored CircE (n = 31)
Power and efficiency
 LV myocardial power/BSA [W/m2] 9.5 ± 3.3 6.9 ± 2.0*+ 7.5 ± 2.6 4.7 ± 1.5*
 Circulatory power [W] 1.3 ± 0.4 1.1 ± 0.4 1.3 ± 0.4 1.3 ± 0.4
 Circulatory efficiency [%] 7.8 ± 3.2 8.5 ± 0.9+ 9.7 ± 3.2 14.9 ± 5.1*
 Circulatory efficiency improvement [%] 0.6 ± 2.8+ 5.2 ± 6.0
Conventional parameters of cardiac vascular function
 Myocardial mass/BSA [mg/m2] 75 ± 23 53 ± 13* 71 ± 21 49 ± 13*
 Myocardial wall thickness end systolic [mm] 11 ± 2 10 ± 1* 11 ± 2 10 ± 2*
 LVEDV/BSA [ml/m2] 99 ± 24 78 ± 14* 92 ± 21 77 ± 13*
 LVESV/BSA [ml/m2] 52 ± 27 34 ± 11* 37 ± 13 30 ± 8*
 Mass-volume-index [g/ml] 0.8 ± 0.1 0.7 ± 0.1* 0.8 ± 0.2 0.7 ± 0.2*
 LVESD [mm] 38 ± 7 33 ± 4* 33 ± 5 31 ± 4*
 Left atrium [cm2] 50 ± 15 43 ± 11 48 ± 17 47 ± 15
 LVP [mmHg] 224 ± 21 164 ± 23* 219 ± 26 154 ± 20*
 Heart rate [bpm] 68 ± 11 67 ± 10 66 ± 11 70 ± 12
 CO_total [l/min] 6.4 ± 1.4 5.8 ± 1.2 7.0 ± 2.0 6.5 ± 1.8
 CI [(l/min)/m2] 3.2 ± 0.7 3.0 ± 0.5 3.6 ± 0.8 3.3 ± 0.8
 SV_total [ml] 73 ± 18 73 ± 14 81 ± 20 77 ± 15
 ECV midwall [%] 24 ± 2 28 ± 5 23 ± 2 27 ± 3*
 aECV midwall [ml] 32 ± 13 28 ± 10 32 ± 11 26 ± 8*
 aECV/BSA midwall [ml/m2] 17 ± 7 15 ± 5 16 ± 5 13 ± 3*
 GLS [%] − 20 ± 6 − 24 ± 4* − 22 ± 5 − 25 ± 4*
 LVEF [%] 50 ± 13+ 57 ± 7* 60 ± 8 62 ± 6
 LGE, n(%) 2 (20%) 2 (20%) 3 (10%) 6 (19%)
Metabolic parameters
 NT-pro-BNP [ng/l] 1356 ± 1570 346 ± 260* 559 ± 427 329 ± 266*
 Hemoglobin [g/dl] 14.7 ± 1.0 13.3 ± 1.0* 14.0 ± 1.4 13.6 ± 1.3*
 Hematocrit [%] 43 ± 3 42.4 ± 3.1 41 ± 4 41.9 ± 3.8
Clinical parameters
 Mean aortic pressure gradient [mmHg] 58 ± 14 15 ± 5*+ 56 ± 16 10 ± 5*
 Systolic blood pressure [mmHg] 140 ± 12 142 ± 21 137 ± 19 136 ± 19
 Diastolic blood pressure [mmHg] 80 ± 6+ 74 ± 8 73 ± 11 75 ± 9
 Pulse pressure [mmHg] 60 ± 14 68 ± 17 63 ± 17 61 ± 15
 NYHA III-IV, n [%] 5 (50%) 1 (10%) 13 (42%) 2 (6%)*
 6-min walk distance [m] 540 ± 32 511 ± 93
  1. LVESD, left ventricular end systolic diameter; EDV, end diastolic volume; ESV, end systolic volume; LA, left atrium; HR, heart rate; CO, cardiac output; CI, cardiac index; SV, stroke volume; LVP, left ventricular pressure; NYHA, New York Heart Association; NT-pro-BNP, N terminales pro brain natriuretic peptide; ECV, extracellular volume; aECV, absolute extracellular volume; GLS, global longitudinal strain; EF, ejection fraction;
  2. *p < 0.05 not restored CircE pre-AVR vs not restored CircE post-AVR or restored CircE pre-AVR vs restored CircE post-AVR
  3.  + p < 0.05 not restored CircE pre-AVR vs restored CircE pre-AVR or not restored CircE post-AVR vs restored CircE post-AVR