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Table 2 Characteristics of Patients Suspected Dilated Cardiomyopathy Stratified by Genetic Status and Exercise Capacity

From: The application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy

 Confirmed DCM (Pathogenic Gene Mutation) (n = 13)No Gene Mutation
Low Exercise Capacity (n = 16)P ValueΠHigh Exercise Capacity (n = 31)P ValueΠ
CLINICAL CHARACTERISTICS
 Age, years43 [22,50]43 [39,48]0.74622 [19,39]0.033
 Males, n (%)11 (85)14 (88)1.00031 (100)0.082
 BSA, m21.86 [1.68,2.00]1.99 [1.88,2.17]0.0751.92 [1.79,2.02]0.537
 BMI, kg/m224.9 [21.8,28.1]30.4 [24.2,35.4]0.13224.1 [20.6,27.3]0.580
 Physical Activity
  Inactive, n (%)4 (31)6 (38)0.4341 (3)0.339
  Moderately Inactive, n (%)2 (15)4 (25)1 (3)
  Moderately Active, n (%)2 (15)4 (25)3 (10)
  Active, n (%)5 (39)2 (12)26 (84)
 Heart Rate, bpm73 [66,79]78 [68,90]0.30860 [53,68]0.004
 Peak Exercise Heart Rate, bpm140 [120,152]134 [119,149]0.650160 [147,165]0.002
 Age-predicted Maximal Heart Rate, %74 [66,87]76 [64,81]0.84682 [75,87]0.168
 Systolic Blood Pressure, mmHg116 [101,136]120 [112,133]0.329126 [118,131]0.102
 Diastolic Blood Pressure, mmHg76 [64,84]81 [69,85]0.47565 [58,79]0.149
 Hypertension, n (%)3 (23)7 (44)0.4333 (10)0.339
 Diabetes, n (%)3 (23)5 (31)0.6971 (3)0.071
 Fam. Hist. of Cardiomyopathy, n (%)2 (15)00.19200.082
 Fam. Hist. of Sudden Cardiac Death, n (%)02 (13)0.48801.000
CMR CHARACTERISTICS
 Indexed LV mass, g/m254 [45,63]69 [55,82]0.00970 [62,76]<0.001
 Indexed LV EDV, mL/m2102 [91,127]106 [88,127]0.914118 [110,130]0.021
 Indexed LV ESV, mL/m259 [48,88]65 [49,81]0.91457 [50,71]0.671
 LV Ejection Fraction, %42 [32,47]41 [34,48]0.88051 [46,55]<0.001
 Indexed RV EDV, mL/m281 [74,106]89 [76,112]0.449125 [112,136]<0.001
 Indexed RV ESV, mL/m245 [36,64]46 [41,63]0.58964 [55,71]0.005
 RV Ejection Fraction, %49 [39,53]46 [43,48]0.88048 [45,51]0.633
 Late gadolinium enhancement (LGE), n (%)5 (38)5 (31)0.7145 (16)0.131
 Amount of LGE (2-SD threshold), %17.1 [11.5,30.8]17.1 [11.5,30.8]1.00010.0 [7.9,19.7]0.222
 Amount of LGE (5-SD threshold), %4.1 [2.1,14.3]4.1 [3.0,10.0]1.0004.1 [1.8,5.7]0.690
 Native T1, ms1047 [1029–1033]1050 [963–1077]1.000987 [977–1033]0.231
 Extracellular volume fraction, %29.2 [27.4,30.9]24.7 [21.7,27.8]0.28622.1 [20.3,29.3]0.308
 Indexed interstitial volume, mL/m214.4 [10.1,18.6]17.1 [14.8,19.7]0.64316.0 [14.0,21.1]0.641
 Circumferential Strain, %−13.3 [−11.3,-16.5]−12.9 [−11.3,-17.5]0.507−17.9 [−15.7,-19.7]<0.001
 Radial Strain, %24.2 [16.7,27.1]18.9 [17.4,28.6]0.83832.2 [28.1,38.0]<0.001
 Longitudinal Strain, %−15.9 [−14.6,-16.2]−14.2 [− 12.3,-16.1]0.474− 17.8 [−16.6,-19.8]0.001
 Change in Exercise LVEF, %49 [34,64]34 [13,49]0.03645 [36,51]0.463
 CI at Rest, L/min/m22.8 [2.3,3.2]3.1 [2.9,3.3]0.0623.4 [3.0,3.9]0.001
 CI at Peak Exercise, L/min/m26.9 [5.8,8.3]7.0 [6.2,7.6]0.94811.4 [10.3,12.7]<0.001
 Change in Exercise CI, %145.8 [101.8182.1]123.8 [87.5160.3]0.423221 [181.6261.3]<0.001
  1. Πcompared to confirmed DCM (Pathogenic Gene Mutation)
  2. Abbreviations: CI Cardiac index