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Table 2 Characteristics of Patients Suspected Dilated Cardiomyopathy Stratified by Genetic Status and Exercise Capacity

From: The application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy

Ā 

Confirmed DCM (Pathogenic Gene Mutation) (nā€‰=ā€‰13)

No Gene Mutation

Low Exercise Capacity (nĀ =ā€‰16)

P ValueĪ 

High Exercise Capacity (nĀ =ā€‰31)

P ValueĪ 

CLINICAL CHARACTERISTICS

ā€ƒAge, years

43 [22,50]

43 [39,48]

0.746

22 [19,39]

0.033

ā€ƒMales, n (%)

11 (85)

14 (88)

1.000

31 (100)

0.082

ā€ƒBSA, m2

1.86 [1.68,2.00]

1.99 [1.88,2.17]

0.075

1.92 [1.79,2.02]

0.537

ā€ƒBMI, kg/m2

24.9 [21.8,28.1]

30.4 [24.2,35.4]

0.132

24.1 [20.6,27.3]

0.580

ā€ƒPhysical Activity

ā€ƒā€ƒInactive, n (%)

4 (31)

6 (38)

0.434

1 (3)

0.339

ā€ƒā€ƒModerately Inactive, n (%)

2 (15)

4 (25)

1 (3)

ā€ƒā€ƒModerately Active, n (%)

2 (15)

4 (25)

3 (10)

ā€ƒā€ƒActive, n (%)

5 (39)

2 (12)

26 (84)

ā€ƒHeart Rate, bpm

73 [66,79]

78 [68,90]

0.308

60 [53,68]

0.004

ā€ƒPeak Exercise Heart Rate, bpm

140 [120,152]

134 [119,149]

0.650

160 [147,165]

0.002

ā€ƒAge-predicted Maximal Heart Rate, %

74 [66,87]

76 [64,81]

0.846

82 [75,87]

0.168

ā€ƒSystolic Blood Pressure, mmHg

116 [101,136]

120 [112,133]

0.329

126 [118,131]

0.102

ā€ƒDiastolic Blood Pressure, mmHg

76 [64,84]

81 [69,85]

0.475

65 [58,79]

0.149

ā€ƒHypertension, n (%)

3 (23)

7 (44)

0.433

3 (10)

0.339

ā€ƒDiabetes, n (%)

3 (23)

5 (31)

0.697

1 (3)

0.071

ā€ƒFam. Hist. of Cardiomyopathy, n (%)

2 (15)

0

0.192

0

0.082

ā€ƒFam. Hist. of Sudden Cardiac Death, n (%)

0

2 (13)

0.488

0

1.000

CMR CHARACTERISTICS

ā€ƒIndexed LV mass, g/m2

54 [45,63]

69 [55,82]

0.009

70 [62,76]

<0.001

ā€ƒIndexed LV EDV, mL/m2

102 [91,127]

106 [88,127]

0.914

118 [110,130]

0.021

ā€ƒIndexed LV ESV, mL/m2

59 [48,88]

65 [49,81]

0.914

57 [50,71]

0.671

ā€ƒLV Ejection Fraction, %

42 [32,47]

41 [34,48]

0.880

51 [46,55]

<0.001

ā€ƒIndexed RV EDV, mL/m2

81 [74,106]

89 [76,112]

0.449

125 [112,136]

<0.001

ā€ƒIndexed RV ESV, mL/m2

45 [36,64]

46 [41,63]

0.589

64 [55,71]

0.005

ā€ƒRV Ejection Fraction, %

49 [39,53]

46 [43,48]

0.880

48 [45,51]

0.633

ā€ƒLate gadolinium enhancement (LGE), n (%)

5 (38)

5 (31)

0.714

5 (16)

0.131

ā€ƒAmount of LGE (2-SD threshold), %

17.1 [11.5,30.8]

17.1 [11.5,30.8]

1.000

10.0 [7.9,19.7]

0.222

ā€ƒAmount of LGE (5-SD threshold), %

4.1 [2.1,14.3]

4.1 [3.0,10.0]

1.000

4.1 [1.8,5.7]

0.690

ā€ƒNative T1, ms

1047 [1029ā€“1033]

1050 [963ā€“1077]

1.000

987 [977ā€“1033]

0.231

ā€ƒExtracellular volume fraction, %

29.2 [27.4,30.9]

24.7 [21.7,27.8]

0.286

22.1 [20.3,29.3]

0.308

ā€ƒIndexed interstitial volume, mL/m2

14.4 [10.1,18.6]

17.1 [14.8,19.7]

0.643

16.0 [14.0,21.1]

0.641

ā€ƒCircumferential Strain, %

āˆ’13.3 [āˆ’11.3,-16.5]

āˆ’12.9 [āˆ’11.3,-17.5]

0.507

āˆ’17.9 [āˆ’15.7,-19.7]

<0.001

ā€ƒRadial Strain, %

24.2 [16.7,27.1]

18.9 [17.4,28.6]

0.838

32.2 [28.1,38.0]

<0.001

ā€ƒLongitudinal Strain, %

āˆ’15.9 [āˆ’14.6,-16.2]

āˆ’14.2 [āˆ’ā€‰12.3,-16.1]

0.474

āˆ’ā€‰17.8 [āˆ’16.6,-19.8]

0.001

ā€ƒChange in Exercise LVEF, %

49 [34,64]

34 [13,49]

0.036

45 [36,51]

0.463

ā€ƒCI at Rest, L/min/m2

2.8 [2.3,3.2]

3.1 [2.9,3.3]

0.062

3.4 [3.0,3.9]

0.001

ā€ƒCI at Peak Exercise, L/min/m2

6.9 [5.8,8.3]

7.0 [6.2,7.6]

0.948

11.4 [10.3,12.7]

<0.001

ā€ƒChange in Exercise CI, %

145.8 [101.8182.1]

123.8 [87.5160.3]

0.423

221 [181.6261.3]

<0.001

  1. Ī compared to confirmed DCM (Pathogenic Gene Mutation)
  2. Abbreviations: CI Cardiac index