TY - JOUR AU - Brown, Louise A. E. AU - Saunderson, Christopher E. D. AU - Das, Arka AU - Craven, Thomas AU - Levelt, Eylem AU - Knott, Kristopher D. AU - Dall’Armellina, Erica AU - Xue, Hui AU - Moon, James C. AU - Greenwood, John P. AU - Kellman, Peter AU - Swoboda, Peter P. AU - Plein, Sven PY - 2021 DA - 2021/03/18 TI - A comparison of standard and high dose adenosine protocols in routine vasodilator stress cardiovascular magnetic resonance: dosage affects hyperaemic myocardial blood flow in patients with severe left ventricular systolic impairment JO - Journal of Cardiovascular Magnetic Resonance SP - 37 VL - 23 IS - 1 AB - Adenosine stress perfusion cardiovascular magnetic resonance (CMR) is commonly used in the assessment of patients with suspected ischaemia. Accepted protocols recommend administration of adenosine at a dose of 140 µg/kg/min increased up to 210 µg/kg/min if required. Conventionally, adequate stress has been assessed using change in heart rate, however, recent studies have suggested that these peripheral measurements may not reflect hyperaemia and can be blunted, in particular, in patients with heart failure. This study looked to compare stress myocardial blood flow (MBF) and haemodynamic response with different dosing regimens of adenosine during stress perfusion CMR in patients and healthy controls. SN - 1532-429X UR - https://doi.org/10.1186/s12968-021-00714-7 DO - 10.1186/s12968-021-00714-7 ID - Brown2021 ER -