A comparison of standard and high dose adenosine protocols in routine vasodilator stress cardiovascular magnetic resonance: dosage affects hyperaemic myocardial blood flow in patients with severe left ventricular systolic impairment

Table 1 Haemodynamic response and MBF in healthy subjects

	Adenosine dosing
	Standard dose: 140 µg/kg/min 4 min duration	High dose: 210 µg/kg/min 4 min duration	Long dose: 140 µg/kg/min 8 min duration	p
Rest HR (bpm)	71 ± 15	71 ± 14	71 ± 13	0.962
Rest SBP (mmHg)	117 ± 12	118 ± 14	117 ± 13	0.481
Stress HR (bpm)	102 ± 19^†	108 ± 16^†	106 ± 19^†	0.017*
Stress SBP (mmHg)	121 ± 16^†	121 ± 16	124 ± 17^‡	0.195
Change in HR (bpm)	30 ± 12	37 ± 11	35 ± 13	0.045*
Change in SBP (mmHg)	5 ± 6	3 ± 9	7 ± 11	0.072
Stress MBF (ml/g/min)	2.50 ± 0.74	2.66 ± 0.59	2.59 ± 0.64	0.323
MPR	3.52 ± 0.93	3.82 ± 0.83	3.72 ± 1.00	0.191

A significant difference was seen in stress heart rate and change in stress HR
HR heart rate, SBP systolic blood pressure, MBF myocardial blood flow, MPR myocardial perfusion reserve
^*Significant difference between adenosine doses, ^†significant difference from rest value, p < 0.05 ^‡significant difference from rest value, p < 0.01. Data given as mean ± standard deviation

ISSN: 1532-429X