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Table 2 Comparison of cardiovascular magnetic resonance imaging findings between the sarcomere gene mutation group and the non-mutation group

From: Effect of sarcomere and mitochondria-related mutations on myocardial fibrosis in patients with hypertrophic cardiomyopathy

 

Presence of sarcomere gene mutation group (n = 41)

Absence of sarcomere gene mutation group (n = 92)

P

LVEDV, mL

133.6 ± 28.6

135.7 ± 28.2

0.698

LVESV, mL

51.7 ± 23.1

46.9 ± 18.5

0.208

LV mass, g

153.7 ± 37.2

152.8 ± 48.0

0.913

LV mass index, g/m2

88.0 ± 21.1

84.7 ± 23.8

0.456

LV mass/volume ratio

1.19 ± 0.32

1.14 ± 0.32

0.469

LV ejection fraction, %

62.5 ± 9.4

65.7 ± 9.8

0.077

Segmental* thickness, mm

   

Thickness in anteroseptal segments

13.0 ± 2.9

11.7 ± 3.2

0.025

Thickness in septal segments

14.4 ± 3.4

12.5 ± 3.6

0.005

Thickness in inferoposterior segments

8.6 ± 2.1

8.9 ± 1.8

0.484

Thickness in lateral segments

7.6 ± 2.2

8.6 ± 2.1

0.020

Thickness in apical segments

10.5 ± 3.2

10.7 ± 3.9

0.771

Late gadolinium enhancement (LGE)

   

Presence of LGE in LV, n (%)

37(90)

55(60)

 < 0.001

Number of LGE segments in LV

4.9 ± 2.8

2.9 ± 3.5

0.002

% LGE amount of LV

10.6 ± 10.1

6.4 ± 9.3

0.040

LGE in anteroseptal segments, %

46.3 ± 25.7

20.7 ± 26.2

 < 0.001

LGE in septal segments, %

47.8 ± 30.0

18.0 ± 26.2

 < 0.001

LGE in inferoposterior segments, %

7.8 ± 14.8

13.5 ± 24.5

0.609

LGE in lateral segments, %

16.6 ± 20.4

14.4 ± 24.3

0.171

LGE in apical segments, %

36.0 ± 37.9

29.1 ± 37.5

0.331

T2, ms

   

T2 average of 16 segments

56.1 ± 3.5

55.3 ± 3.0

0.177

T2 in anteroseptal segments

56.9 ± 3.7

55.3 ± 3.0

0.242

T2 in septal segments

57.9 ± 4.0

57.2 ± 3.7

0.360

T2 in inferoposterior segments

55.9 ± 3.7

54.8 ± 3.3

0.117

T2 in lateral segments

54.9 ± 4.0

54.0 ± 3.3

0.193

T2 in apical segments

57.1 ± 5.6

56.7 ± 4.3

0.677

Native T1, ms

   

T1 average of 16 segments

1025 ± 47

1019 ± 49

0.512

T1 in anteroseptal segments

1023 ± 46

1017 ± 51

0.524

T1 in septal segments

10343 ± 44

1024 ± 49

0.301

T1 in inferoposterior segments

1045 ± 59

1032 ± 54

0.216

T1 in lateral segments

1014 ± 59

1013 ± 54

0.921

T1 in apical segments

1009 ± 66

1017 ± 58

0.469

Post contrast T1, ms

   

T1 average of 16 segments

579 ± 59

607 ± 63

0.021

T1 in anteroseptal segments

569 ± 66

603 ± 64

0.008

T1 in septal segments

574 ± 66

608 ± 63

0.007

T1 in inferoposterior segments

595 ± 53

616 ± 63

0.065

T1 in lateral segments

590 ± 56

611 ± 65

0.085

T1 in apical segments

564 ± 57

588 ± 66

0.051

Extracellular volume fraction (ECV), %

   

ECV average of 16 segments

34.2 ± 4.8

31.4 ± 4.3

0.001

ECV in anteroseptal segments

35.8 ± 6.8

31.8 ± 4.4

0.001

ECV in septal segments

35.7 ± 6.7

31.4 ± 4.1

 < 0.001

ECV in inferoposterior segments

32.7 ± 4.0

30.8 ± 4.5

0.022

ECV in lateral segments

31.8 ± 3.9

30.7 ± 5.1

0.235

ECV in apical segments

35.3 ± 4.6

33.7 ± 5.5

0.118

  1. LV left ventricular, LVEDV LV end-diastolic volume, LVESV LV end-systolic volume