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Table 2 Comparison of cardiovascular magnetic resonance imaging findings between the sarcomere gene mutation group and the non-mutation group

From: Effect of sarcomere and mitochondria-related mutations on myocardial fibrosis in patients with hypertrophic cardiomyopathy

  Presence of sarcomere gene mutation group (n = 41) Absence of sarcomere gene mutation group (n = 92) P
LVEDV, mL 133.6 ± 28.6 135.7 ± 28.2 0.698
LVESV, mL 51.7 ± 23.1 46.9 ± 18.5 0.208
LV mass, g 153.7 ± 37.2 152.8 ± 48.0 0.913
LV mass index, g/m2 88.0 ± 21.1 84.7 ± 23.8 0.456
LV mass/volume ratio 1.19 ± 0.32 1.14 ± 0.32 0.469
LV ejection fraction, % 62.5 ± 9.4 65.7 ± 9.8 0.077
Segmental* thickness, mm    
Thickness in anteroseptal segments 13.0 ± 2.9 11.7 ± 3.2 0.025
Thickness in septal segments 14.4 ± 3.4 12.5 ± 3.6 0.005
Thickness in inferoposterior segments 8.6 ± 2.1 8.9 ± 1.8 0.484
Thickness in lateral segments 7.6 ± 2.2 8.6 ± 2.1 0.020
Thickness in apical segments 10.5 ± 3.2 10.7 ± 3.9 0.771
Late gadolinium enhancement (LGE)    
Presence of LGE in LV, n (%) 37(90) 55(60)  < 0.001
Number of LGE segments in LV 4.9 ± 2.8 2.9 ± 3.5 0.002
% LGE amount of LV 10.6 ± 10.1 6.4 ± 9.3 0.040
LGE in anteroseptal segments, % 46.3 ± 25.7 20.7 ± 26.2  < 0.001
LGE in septal segments, % 47.8 ± 30.0 18.0 ± 26.2  < 0.001
LGE in inferoposterior segments, % 7.8 ± 14.8 13.5 ± 24.5 0.609
LGE in lateral segments, % 16.6 ± 20.4 14.4 ± 24.3 0.171
LGE in apical segments, % 36.0 ± 37.9 29.1 ± 37.5 0.331
T2, ms    
T2 average of 16 segments 56.1 ± 3.5 55.3 ± 3.0 0.177
T2 in anteroseptal segments 56.9 ± 3.7 55.3 ± 3.0 0.242
T2 in septal segments 57.9 ± 4.0 57.2 ± 3.7 0.360
T2 in inferoposterior segments 55.9 ± 3.7 54.8 ± 3.3 0.117
T2 in lateral segments 54.9 ± 4.0 54.0 ± 3.3 0.193
T2 in apical segments 57.1 ± 5.6 56.7 ± 4.3 0.677
Native T1, ms    
T1 average of 16 segments 1025 ± 47 1019 ± 49 0.512
T1 in anteroseptal segments 1023 ± 46 1017 ± 51 0.524
T1 in septal segments 10343 ± 44 1024 ± 49 0.301
T1 in inferoposterior segments 1045 ± 59 1032 ± 54 0.216
T1 in lateral segments 1014 ± 59 1013 ± 54 0.921
T1 in apical segments 1009 ± 66 1017 ± 58 0.469
Post contrast T1, ms    
T1 average of 16 segments 579 ± 59 607 ± 63 0.021
T1 in anteroseptal segments 569 ± 66 603 ± 64 0.008
T1 in septal segments 574 ± 66 608 ± 63 0.007
T1 in inferoposterior segments 595 ± 53 616 ± 63 0.065
T1 in lateral segments 590 ± 56 611 ± 65 0.085
T1 in apical segments 564 ± 57 588 ± 66 0.051
Extracellular volume fraction (ECV), %    
ECV average of 16 segments 34.2 ± 4.8 31.4 ± 4.3 0.001
ECV in anteroseptal segments 35.8 ± 6.8 31.8 ± 4.4 0.001
ECV in septal segments 35.7 ± 6.7 31.4 ± 4.1  < 0.001
ECV in inferoposterior segments 32.7 ± 4.0 30.8 ± 4.5 0.022
ECV in lateral segments 31.8 ± 3.9 30.7 ± 5.1 0.235
ECV in apical segments 35.3 ± 4.6 33.7 ± 5.5 0.118
  1. LV left ventricular, LVEDV LV end-diastolic volume, LVESV LV end-systolic volume