Table 1 Baseline and CMR Characteristics of Patients with and without Myocardial Ischemia (N = 1342)
All patients (N = 1342) | No ischemia (N = 966) | Ischemia (N = 376) | p value | |
|---|---|---|---|---|
Age (years) | 67.7 ± 10.5 | 67.2 ± 10.7 | 69.0 ± 9.3 | 0.003 |
Males, n (%) | 1101 (82.0) | 781 (80.8) | 320 (85.1) | 0.024 |
Body mass index (kg/m2) | 27.2 ± 4.0 | 27.1 ± 3.9 | 27.5 ± 4.0 | 0.135 |
Coronary risk factors, n (%) | ||||
Diabetes mellitus | 409 (30.5) | 258 (26.7) | 151 (40.2) | < 0.001 |
Hypertension | 691 (51.5) | 468 (48.4) | 223 (59.3) | < 0.001 |
Dyslipidemia | 849 (63.3) | 589 (61.0) | 260 (69.1) | 0.006 |
Current or previous smoking | 324 (24.1) | 244 (25.3) | 80 (21.3) | 0.144 |
Family history of CAD | 431 (32.1) | 309 (32.0) | 122 (32.4) | 0.923 |
Obesitya | 310 (23.1) | 220 (22.8) | 90 (23.9) | 0.703 |
Medical history of CV disease, n (%) | ||||
Prior PCI | 735 (54.8) | 552 (57.1) | 183 (48.7) | 0.006 |
Prior CABG | 431 (32.1) | 309 (32.0) | 122 (32.4) | 0.923 |
Prior MI | 746 (55.6) | 570 (59.0) | 176 (46.8) | < 0.001 |
Peripheral atheroma | 115 (8.6) | 64 (6.6) | 51 (13.6) | < 0.001 |
Ischemic stroke | 35 (2.6) | 28 (2.9) | 7 (1.9) | 0.379 |
Pacemaker | 2 (0.1) | 1 (0.1) | 1 (0.3) | 0.482 |
Renal failureb | 16 (1.2) | 12 (1.2) | 4 (1.1) | 1.000 |
Heart failure hospitalization | 31 (2.3) | 24 (2.5) | 7 (1.9) | 0.631 |
Indications to stress CMR (multiple possible), n (%) | ||||
PCI or CABG follow-upc | 1184 (88.2) | 830 (85.9) | 354 (94.1) | < 0.001 |
Inconclusive stress test | 107 (8.0) | 65 (6.7) | 42 (11.2) | 0.01 |
Inconclusive CCTAd | 110 (8.2) | 60 (6.2) | 50 (13.3) | < 0.001 |
Cardiac rhythm, n (%) | ||||
Sinus rhythm | 1151 (85.8) | 818 (84.7) | 333 (88.6) | |
Sinus rhythm with extrasystoles | 185 (13.8) | 145 (15.0) | 40 (10.6) | 0.039 |
Atrial fibrillation/supraventricular arrhythmias | 6 (0.4) | 3 (0.3) | 3 (0.8) | |
LV ejection fraction, % | 45.8 ± 12.5 | 45.1 ± 12.5 | 47.7 ± 12.5 | < 0.001 |
LV end-diastolic volume index, ml/m2 | 100.2 ± 31.3 | 102.2 ± 32.1 | 95.1 ± 28.4 | < 0.001 |
LV end-systolic volume index, ml/m2 | 57.1 ± 27.4 | 58.9 ± 27.7 | 52.2 ± 25.8 | < 0.001 |
LV mass, g/m2 | 73.8 ± 7.1 | 73.6 ± 7.2 | 73.5 ± 7.1 | 0.319 |
RV ejection fraction, % | 57.2 ± 11.2 | 57.1 ± 11.3 | 57.3 ± 12.9 | 0.429 |
Presence of LGE, n (%) | 689 (51.3) | 502 (52.0) | 187 (49.7) | 0.018 |
Presence of viabilitye, n (%) | 280 (20.9) | 175 (18.1) | 105 (27.9) | < 0.001 |
Number of segments of LGE | 2.3 ± 1.9 | 2.4 ± 1.9 | 2.2 ± 2.0 | 0.268 |
Number of segments of myocardial ischemia | 0.7 ± 1.5 | 0.0 ± 0.0 | 2.5 ± 1.7 | < 0.001 |
HR at baseline, beats/min | 67 ± 12 | 67 ± 12 | 71 ± 13 | 0.512 |
HR at stress, beats/min | 91 ± 9 | 90 ± 9 | 96 ± 11 | 0.069 |
RPP at baseline (k), mmHg-beats/min | 9.1 (7.5–10.6) | 9.0 (7.5–10.6) | 9.2 (7.5–11.0) | 0.621 |
RPP at stress (k), mmHg-beats/min | 10.6 (9.0–12.4) | 10.4 (9.0–12.4) | 10.9 (9.5–12.8) | 0.193 |