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Table 3 Multivariable cox regression analysis for the prediction of adverse events (N = 1342)

From: Prognostic value of stress cardiovascular magnetic resonance in asymptomatic patients with known coronary artery disease

  MACE Cardiovascular Mortality
Hazard ratio
(95% CI)
p value Hazard ratio
(95% CI)
p value
Model 1a     
 Age 1.03 (1.01–1.04)  < 0.001 1.06 (1.04–1.08)  < 0.001
 Hypertension 0.72 (0.54–0.96) 0.026 0.70 (0.47–1.04) 0.073
 Dyslipidemia 0.76 (0.51–1.12) 0.168
 Prior PCI 0.51 (0.34–0.76) 0.001
 LVEF, per 10% 0.87 (0.78–0.97) 0.028 0.89 (0.76–1.05) 0.211
 LV end-systolic volume index, per 10 ml/m2 1.10 (1.05–1.16)  < 0.001 1.13 (1.05–1.21) < 0.001
Model 2b     
 Presence of myocardial ischemia 2.80 (2.10–3.73)  < 0.001 2.20 (1.47–3.28)  < 0.001
 Presence of LGE 1.51 (1.01–2.27) 0.045 2.07 (1.13–3.78) 0.018
Model 3c     
 Age 1.03 (1.01–1.04)  < 0.001 1.06 (1.03–1.08)  < 0.001
 Male 1.17 (0.79–1.72) 0.424 1.25 (0.72–2.17) 0.424
 Body mass index 0.98 (0.94–1.00) 0.233 0.95 (0.63–1.52) 0.851
 Hypertension 0.72 (0.53–0.98) 0.037 0.68 (0.44–1.03) 0.068
 Diabetes mellitus 0.95 (0.69–1.31) 0.748 1.23 (0.80–1.88) 0.344
 Dyslipidemia 0.97 (0.72–1.31) 0.831 0.78 (0.52–1.19) 0.251
 Current or previous smoking 1.13 (0.81–1.58) 0.477 1.17 (0.72–1.88) 0.523
 LVEF, per 10% 0.81 (0.72–0.92)  < 0.001 0.83 (0.70–0.98) 0.024
Model 4d     
 Presence of myocardial ischemia 2.85 (2.13–3.81)  < 0.001 2.16 (1.44–3.24)  < 0.001
 Presence of LGE 0.98 (0.97–0.99) 0.005 1.89 (1.05–3.41) 0.034
  1. aCovariates in the model 1 by stepwise variable selection with entry and exit criteria set at the p ≤ 0.2 level:
  2. for MACE: age, hypertension, LVEF per 10% and LV end-systolic volume index, per 10 ml/m2.
  3. for CV mortality: age, hypertension, dyslipidemia, previous PCI, LVEF per 10% and LV end-systolic volume index, per 10 ml/m2.
  4. bCovariates in the model 2: model 1 + presence of myocardial ischemia and LGE
  5. cCovariates in the model 3 were traditional cardiovascular risk factors: age, male, BMI, hypertension, diabetes mellitus, current or previous smoking, dyslipidemia and LVEF per 10%
  6. dCovariates in the model 4: model 3 + presence of myocardial ischemia and LGE
  7. CI confidence interval, EDVi end-diastolic volume index, ESVi end-systolic volume index, HR hazard ratio, LGE late gadolinium enhancement, MACE major adverse cardiac events, LV left ventricle, LVEF left ventricular ejection fraction