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Table 3 Multivariable cox regression analysis for the prediction of adverse events (N = 1342)

From: Prognostic value of stress cardiovascular magnetic resonance in asymptomatic patients with known coronary artery disease

 

MACE

Cardiovascular Mortality

Hazard ratio

(95% CI)

p value

Hazard ratio

(95% CI)

p value

Model 1a

    

 Age

1.03 (1.01–1.04)

 < 0.001

1.06 (1.04–1.08)

 < 0.001

 Hypertension

0.72 (0.54–0.96)

0.026

0.70 (0.47–1.04)

0.073

 Dyslipidemia

0.76 (0.51–1.12)

0.168

 Prior PCI

0.51 (0.34–0.76)

0.001

 LVEF, per 10%

0.87 (0.78–0.97)

0.028

0.89 (0.76–1.05)

0.211

 LV end-systolic volume index, per 10 ml/m2

1.10 (1.05–1.16)

 < 0.001

1.13 (1.05–1.21)

< 0.001

Model 2b

    

 Presence of myocardial ischemia

2.80 (2.10–3.73)

 < 0.001

2.20 (1.47–3.28)

 < 0.001

 Presence of LGE

1.51 (1.01–2.27)

0.045

2.07 (1.13–3.78)

0.018

Model 3c

    

 Age

1.03 (1.01–1.04)

 < 0.001

1.06 (1.03–1.08)

 < 0.001

 Male

1.17 (0.79–1.72)

0.424

1.25 (0.72–2.17)

0.424

 Body mass index

0.98 (0.94–1.00)

0.233

0.95 (0.63–1.52)

0.851

 Hypertension

0.72 (0.53–0.98)

0.037

0.68 (0.44–1.03)

0.068

 Diabetes mellitus

0.95 (0.69–1.31)

0.748

1.23 (0.80–1.88)

0.344

 Dyslipidemia

0.97 (0.72–1.31)

0.831

0.78 (0.52–1.19)

0.251

 Current or previous smoking

1.13 (0.81–1.58)

0.477

1.17 (0.72–1.88)

0.523

 LVEF, per 10%

0.81 (0.72–0.92)

 < 0.001

0.83 (0.70–0.98)

0.024

Model 4d

    

 Presence of myocardial ischemia

2.85 (2.13–3.81)

 < 0.001

2.16 (1.44–3.24)

 < 0.001

 Presence of LGE

0.98 (0.97–0.99)

0.005

1.89 (1.05–3.41)

0.034

  1. aCovariates in the model 1 by stepwise variable selection with entry and exit criteria set at the p ≤ 0.2 level:
  2. for MACE: age, hypertension, LVEF per 10% and LV end-systolic volume index, per 10 ml/m2.
  3. for CV mortality: age, hypertension, dyslipidemia, previous PCI, LVEF per 10% and LV end-systolic volume index, per 10 ml/m2.
  4. bCovariates in the model 2: model 1 + presence of myocardial ischemia and LGE
  5. cCovariates in the model 3 were traditional cardiovascular risk factors: age, male, BMI, hypertension, diabetes mellitus, current or previous smoking, dyslipidemia and LVEF per 10%
  6. dCovariates in the model 4: model 3 + presence of myocardial ischemia and LGE
  7. CI confidence interval, EDVi end-diastolic volume index, ESVi end-systolic volume index, HR hazard ratio, LGE late gadolinium enhancement, MACE major adverse cardiac events, LV left ventricle, LVEF left ventricular ejection fraction