Skip to main content

Table 4 Comparison of idiopathic LBBB patients with isolated ventricular asynchrony, with superimposed contractile impairment and control group A with cardiovascular  disease risk factors

From: Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block

CMR measurements

LBBB with isolated asynchrony (n = 33)

LBBB with superimposed hypocontractility (n = 20)

control group A CVRF ( +) (n = 53)

ANOVA

Bonferroni Post-Hoc

LBBB with isolated asynchrony vs. control group A

LBBB with superimposed hypocontractility vs. control group A

p

LBBB with isolated asynchrony vs. LBBB with superimposed hypocontractility

LVEDVI (ml/m2)

78.1 ± 14.3

89.8 ± 14.0

71.8 ± 9.9

 < 0.001

 < 0.01

0.059

 < 0.001

corrected LV-EF (%)

62.9 ± 3.6

55.9 ± 2.8

62.9 ± 4.2

 < 0.001

 < 0.001

1.000

 < 0.001

RV-EDVI (ml/m2)

65.0 ± 9.7

74.2 ± 11.7

68.8 ± 11.8

 < 0.05

 < 0.05

0.382

0.209

RV-EF (%)

66.9 ± 5.3

60.4 ± 6.8

65.0 ± 6.7

 < 0.05

 < 0.01

0.576

 < 0.05

GCS

− 18.5 ± 2.9

− 15.9 ± 2.4

− 20.5 ± 2.5

 < 0.001

 < 0.01

 < 0.01

 < 0.001

GLS

− 16.4 ± 3.3

− 14.5 ± 1.8

− 18.2 ± 2.3

 < 0.001

 < 0.05

 < 0.05

 < 0.001

LV mass (g)

93 ± 25

103 ± 30

88 ± 22

0.068

0.397

1.000

0.062

Native T1 times

1.5 T

n = 14

n = 8

n = 22

    

 Global (ms)

1015 ± 24

1035 ± 24

1009 ± 20

 < 0.05

0.144

1.000

 < 0.05

 Septal (ms)

1039 ± 24

1059 ± 36

1022 ± 22

 < 0.01

0.271

0.185

 < 0.01

 Lateral (ms)

1015 ± 30

1021 ± 23

1006 ± 29

0.377

1.000

1.000

0.606

3 T

n = 11

n = 8

n = 26

    

 Global (ms)

1253 ± 35

1271 ± 43

1238 ± 25

 < 0.05

0.651

0.575

 < 0.05

 Septal (ms)

1282 ± 54

1308 ± 60

1256 ± 30

 < 0.05

0.578

0.294

 < 0.05

 Lateral (ms)

1222 ± 28

1230 ± 57

1226 ± 30

0.875

1.000

1.000

1.000

LGE

n = 3

n = 5

 

T-Test

   
    

p

   

Enhanced myocardial mass (g)

1.01 ± 0.11

1.99 ± 0.43

 < 0.01

Relative enhanced myocardial mass (%)

1.27 ± 0.26

2.00 ± 0.44

 < 0.05

Biomarkers

   

Mann–Whitney-Test

   

NT-proBNP (< 125 ng/l)

99 (49–152)

133 (104–239)

0.231

High sensitive Troponin T (< 14 pg/ml)

11 (7–16)

6 (5–11)

0.063

  1. CVRF cardiovascular risk factors, LV left ventricle, EDVI end-diastolic volume index, EF ejection fraction, RV right ventricle, GCS global circumferential strain, GLS global longitudinal strain, LGE late gadolinium enhancement, NT-proBNP N-terminal pro B-type Natriuretic Peptide. Values are mean ± standard deviation. Differences between all three groups were calculated using 2-way ANOVA and Bonferroni-Posttest. Differences in between the LBBB subgroups were calculated using T-Test or Mann–Whitney-Test