CMR measurements | LBBB with isolated asynchrony (n = 33) | LBBB with superimposed hypocontractility (n = 20) | control group A CVRF ( +) (n = 53) | ANOVA | Bonferroni Post-Hoc | LBBB with isolated asynchrony vs. control group A | LBBB with superimposed hypocontractility vs. control group A |
---|---|---|---|---|---|---|---|
p | LBBB with isolated asynchrony vs. LBBB with superimposed hypocontractility | ||||||
LVEDVI (ml/m2) | 78.1 ± 14.3 | 89.8 ± 14.0 | 71.8 ± 9.9 | < 0.001 | < 0.01 | 0.059 | < 0.001 |
corrected LV-EF (%) | 62.9 ± 3.6 | 55.9 ± 2.8 | 62.9 ± 4.2 | < 0.001 | < 0.001 | 1.000 | < 0.001 |
RV-EDVI (ml/m2) | 65.0 ± 9.7 | 74.2 ± 11.7 | 68.8 ± 11.8 | < 0.05 | < 0.05 | 0.382 | 0.209 |
RV-EF (%) | 66.9 ± 5.3 | 60.4 ± 6.8 | 65.0 ± 6.7 | < 0.05 | < 0.01 | 0.576 | < 0.05 |
GCS | − 18.5 ± 2.9 | − 15.9 ± 2.4 | − 20.5 ± 2.5 | < 0.001 | < 0.01 | < 0.01 | < 0.001 |
GLS | − 16.4 ± 3.3 | − 14.5 ± 1.8 | − 18.2 ± 2.3 | < 0.001 | < 0.05 | < 0.05 | < 0.001 |
LV mass (g) | 93 ± 25 | 103 ± 30 | 88 ± 22 | 0.068 | 0.397 | 1.000 | 0.062 |
Native T1 times | |||||||
1.5 T | n = 14 | n = 8 | n = 22 | ||||
Global (ms) | 1015 ± 24 | 1035 ± 24 | 1009 ± 20 | < 0.05 | 0.144 | 1.000 | < 0.05 |
Septal (ms) | 1039 ± 24 | 1059 ± 36 | 1022 ± 22 | < 0.01 | 0.271 | 0.185 | < 0.01 |
Lateral (ms) | 1015 ± 30 | 1021 ± 23 | 1006 ± 29 | 0.377 | 1.000 | 1.000 | 0.606 |
3 T | n = 11 | n = 8 | n = 26 | ||||
Global (ms) | 1253 ± 35 | 1271 ± 43 | 1238 ± 25 | < 0.05 | 0.651 | 0.575 | < 0.05 |
Septal (ms) | 1282 ± 54 | 1308 ± 60 | 1256 ± 30 | < 0.05 | 0.578 | 0.294 | < 0.05 |
Lateral (ms) | 1222 ± 28 | 1230 ± 57 | 1226 ± 30 | 0.875 | 1.000 | 1.000 | 1.000 |
LGE | n = 3 | n = 5 | T-Test | ||||
p | |||||||
Enhanced myocardial mass (g) | 1.01 ± 0.11 | 1.99 ± 0.43 | – | < 0.01 | – | – | – |
Relative enhanced myocardial mass (%) | 1.27 ± 0.26 | 2.00 ± 0.44 | – | < 0.05 | – | – | – |
Biomarkers | Mann–Whitney-Test | ||||||
NT-proBNP (< 125 ng/l) | 99 (49–152) | 133 (104–239) | – | 0.231 | – | – | – |
High sensitive Troponin T (< 14 pg/ml) | 11 (7–16) | 6 (5–11) | – | 0.063 | – | – | – |