Fig. 5

Impact of the arterial input function (AIF) sampling location on ischemic burden and clinical interpretation. Example stress perfusion images (top), pixel-wise MBF maps (bottom-left) and corresponding 16-segment bullseye plots (bottom-right) of myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) demonstrating the impact on ischemic burden in a patient with widespread ischemia for the clinical reference basal left ventricle (bLV) and the aortic root (AoR). The mean stress MBF is 2.38 mL/g/min and 1.65 mL/g/min for the bLV and AoR respectively, and the mean MPR is 1.36 and 1.44 for the bLV and AoR respectively. The percent ischemic burden (given below each plot) was measured using the same AoR-derived cut-off values (stress MBF ≤ 2.02 mL/g/min and MPR ≤ 1.88), though a corresponding effect is observed using values for alternative locations