Table 1 Baseline characteristics of HCM patients and healthy volunteers
Variable | Healthy subjects (n = 100) | HCM (n = 359) | P | HCMR Patients without combined outcome (n = 300) | HCM Patients with combined outcome (n = 59) | P | HCM Patients with LA diameter > 41 mm (n = 135) | HCM Patients with LA diameter ≤ 41 mm (n = 224) | P |
|---|---|---|---|---|---|---|---|---|---|
Clinical data | |||||||||
Age, years | 47 (36,66) | 49 (39,60) | 0.746 | 48 (36,55) | 60 (49,69) | < 0.001* | 52.3 ± 13.3 | 45.2 ± 17.3 | < 0.001* |
Male gender, n (%) | 43 (43.0) | 198 (55.2) | 0.031* | 171 (57.0) | 27 (45.7) | 0.113 | 64 (47.4) | 134 (59.8) | 0.022 |
BMI (kg/m2) | 22.7 (20.7,24.3) | 23.7 (21.5,25.6) | 0.004* | 23.7 (21.5,25.5) | 23.6 (21.3,25.8) | 0.754 | 24.2 (22.2,26.2) | 23.3 (20.8,25.4) | 0.001* |
BSA (m2) | 1.6 ± 0.2 | 1.7 ± 0.2 | < 0.001* | 1.7 ± 0.2 | 1.6 ± 0.2 | 0.033* | 1.7 (1.6,1.8) | 1.7 (1.5,1.8) | 0.316 |
Heart rate (beat/minute) | 72 (66,78) | 73 (65,77) | 0.654 | 73 (66,76) | 71 (63,78) | 0.431 | 73 (65,80) | 73 (66,75) | 0.164 |
Diabetes mellitus, n (%) | – | 24 (6.7) | – | 20 (6.7) | 4 (6.8) | 1.000 | 12 (8.9) | 12 (5.4) | 0.194 |
Hypertension, n (%) | – | 82 (22.8) | – | 62 (20.7) | 20 (33.9) | 0.027* | 36 (26.7) | 46 (20.5) | 0.180 |
Obstructive HCM, n (%) | – | 137 (38.2) | – | 103 (34.3) | 34 (57.6) | 0.001* | 67 (49.6) | 70 (31.3) | 0.001* |
Family history of SCD, n (%) | – | 49 (13.6) | – | 39 (13.0) | 10 (16.9) | 0.419 | 18 (13.3) | 31 (13.8) | 0.892 |
History of syncope, n (%) | – | 65 (18.1) | – | 50 (16.7) | 15 (25.4) | 0.110 | 24 (17.8) | 41 (18.3) | 0.900 |
CAD, n (%) | – | 27 (7.5) | – | 21 (7.0) | 6 (10.2) | 0.566 | 15 (11.1) | 12 (5.4) | 0.045* |
Cardiac medications | |||||||||
β blocker, n (%) | – | 239 (66.6) | – | 194 (64.7) | 45 (76.3) | 0.084 | 102 (75.6) | 137 (61.2) | 0.005* |