Table 1 Baseline clinical and CMR characteristics of controls and HFpEF patients
Variable | Controls (N = 26) | HFpEF (N = 45) | P value |
|---|---|---|---|
Age (years) | 58.4 ± 12.3 | 64.3 ± 8.8 | 0.025 |
Male (n, %) | 21 (80.8%) | 34 (75.6%) | 0.618 |
Race—White (n, %) | 16 (61.5%) | 15 (33.3%) | 0.046 |
Race—African American (n, %) | 10 (38.5%) | 29 (64.4%) | 0.034 |
BMI (kg/m2) | 29.4 ± 5.6 | 36.5 ± 6.7 | < 0.001 |
BMI > 30 (kg/m2) | 10 (38.5%) | 36 (80.0%) | < 0.001 |
Cardiovascular related factors | |||
Systolic blood pressure (mmHg) | 139 ± 19 | 151 ± 20 | 0.016 |
Diastolic blood pressure (mmHg) | 79 ± 13 | 87 ± 12 | 0.016 |
Hypertension (n, %) | 16 (61.5%) | 41 (91.1%) | 0.002 |
Coronary artery disease (n, %) | 4 (15.4%) | 16 (35.6%) | 0.070 |
Myocardial infarction (n, %) | 1 (3.8%) | 6 (13.3%) | 0.296 |
Hyperlipidemia (n, %) | 15 (57.7%) | 38 (84.4%) | 0.012 |
CVA or TIA (n, %) | 2 (7.7%) | 4 (8.9%) | 0.864 |
Sleep apnea (n, %) | 0 (0.0%) | 22 (48.9%) | < 0.001 |
Smoker (n, %) | 9 (34.6%) | 8 (18.2%) | 0.125 |
CMR LV parameters | |||
LVEDV index (ml/m2) | 73.2 ± 13.1 | 75.1 ± 16.0 | 0.598 |
LVESV index (ml/m2) | 25.6 ± 7.2 | 29.2 ± 9.6 | 0.100 |
LV SV index (ml/m2) | 47.6 ± 8.6 | 45.9 ± 10.6 | 0.490 |
LVEF (%) | 65.1 ± 6.4 | 61.6 ± 7.6 | 0.039 |