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Fig. 2 | Journal of Cardiovascular Magnetic Resonance

Fig. 2

From: Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy

Fig. 2

Hypertrophic cardiomyopathy (HCM) mice carrying mybpc3 and myh7 gene variants show myocardial hypertrophy. a Representative FLASH cine images (upper row: end-diastole; lower row: end-systole) show mid-ventricular short axis (SAX) views in male B6 (C57BL/6) and D2 (DBA/2J) mouse heart acquired at 9.4 T. Yellow lines outline the thickness of left ventricle (LV). White scale bar = 1 mm. b cine-CMR revealed preserved LV function in D2 HCM mice (male: n = 4, female: n = 4) compared to B6 (male n = 4, female n = 4). Functional assessments (LV thickness, LV ejection fraction (LVEF), data are shown as mean ± SD) were done on a slice-by-slice basis. Endo- and epi-cardiac borders were manually segmented in end-systole and end-diastole using a stack of short axis FLASH cine images. LVEF were calculated for both sexes. Data are shown as the mean ± SD. **p < 0.01, ***p < 0.001 using one-way ANOVA with Tukey’s multiple-comparisons test

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