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Fig. 2 | Journal of Cardiovascular Magnetic Resonance

Fig. 2

From: Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension

Fig. 2

RV ejection fraction (RVEF) and RV systolic pressure (RVSP) are comparable between pulmonary artery hypertension (PAH) patients and PAB mice. a RVEF is reduced in PAH subjects (57 ± 6% in PAH versus 44 ± 9% in controls, p < 0.001) and PAB mice (62 ± 7% in PAB versus 37 ± 11% in Sham, p < 0.001) compared to control (CTRL) subjects and Sham mice, b RVSP is significantly increased in both PAH patients (63 ± 23 mmHg, p < 0.001) versus known healthy values [55], and PAB mice (64 ± 16 mmHg, p < 0.001) relative to Sham mice (19 ± 1 mmHg). Note, RVSP was not measured for control subjects. Variables were compared between control and hypertensive groups using a Student’s unpaired t-test with an α = 0.05. Data is expressed as mean ± SD. n = 18 in PAH cohort; n = 17 in control cohort; n = 12 in PAB group; n = 9 in Sham group

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