Fig. 3

LV torsional mechanics are significantly different between Sham mice and PAB mice and comparable to human subjects. a LV torsion rate is reduced in PAH subjects (1.4 ± 0.6°/τ) and PAB mice (0.8 ± 0.6°/τ) compared to CTRL subjects (3.0 ± 1.5°/τ) and Sham mice (4.2 ± 1.4°/τ) (p < 0.001, p = 0.004, respectively) where τ is the period of % systole, b LV torsion rate is associated with RV contractility in PAB mice (▲, r = 0.91, p < 0.05) and strongly associated in PAH subjects (●, r = 0.51, p < 0.04), c Apical rotation, basal rotation, torsion are shown for control subjects (●, blue), PAH subjects (●, red), Sham mice (▲, blue), and PAB mice (▲, red) with error bars at intervals of 10%. Variables were compared between control and hypertensive groups using a Student’s unpaired t-test with an α = 0.05. Correlation coefficients were derived using univariate linear regression with an α = 0.05. Data are expressed as mean ± SD. n = 18 in PAH cohort; n = 17 in control cohort; n = 12 in PAB group; n = 9 in Sham group