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Fig. 5 | Journal of Cardiovascular Magnetic Resonance

Fig. 5

From: Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension

Fig. 5

RV and LV global peak strains are significantly reduced in PAH subjects and PAB mice. a LV peak radial (26 ± 23% versus 33.9 ± 2%, p = 0.002) and circumferential (− 16 ± 1% versus − 18 ± 1%, p < 0.04) strain are reduced in PAB compared to Sham mice, while in children just LV peak circumferential strain (− 15 ± 4% versus -20 ± 2%, p < 0.02) is reduced in PAH compared to CTRL subjects. b RV peak radial (25 ± 3% versus 34 ± 3%, p = 0.002), circumferential (− 16 ± 1% versus − 19 ± 1%, p < 0.001) and longitudinal (− 18 ± 1% versus − 20 ± 1%, p = 0.02) strain are reduced in PAB compared to Sham mice, while in children peak radial (16 ± 5% versus 21 ± 8%, p < 0.05) and longitudinal (− 18 ± 4% versus − 20 ± 5%, p < 0.01) are reduced in PAH compared to CTRL subjects. Strain variables were compared between control and hypertensive groups using a Student’s unpaired t-test with an α = 0.05. Data are expressed as mean ± SD. n = 18 in PAH cohort; n = 17 in control cohort; n = 12 in PAB group; n = 9 in Sham group

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