Fig. 2

Cardiac structural and functional changes in patients with Wilson Disease with and without neurological symptoms. Comparison of Wilson Disease (WD) patients without neurological symptoms (WD-neuro−), with neurological symptoms (WD-neuro+) and healthy controls: Septum (mm) (a); Left ventricular global circumferential strain (LV-GCS (%)) (b), global native T1 time (ms) (c) and extracellular volume fraction (ECV) (%) (d) in 1.5-T CMR. Differences between all three groups were calculated using 2-way ANOVA or Kruskal–Wallis test, * p < 0.05 vs. controls; **p < 0.01 vs. controls; $p < 0.05 vs. WD neuro− (t-test)