The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study

Table 3 Cardiac morphology and function of patients with Wilson Disease

	WD	Controls	p	WD-neuro⁻	WD-neuro⁺	p
CMR Measurements	n = 76	n = 76		n = 43	n = 33
LV EDV indexed (ml/m²)	81 ± 13	80 ± 11	0.57	82 ± 13	79 ± 14	0.41
LVEF (%)	63 ± 5	64 ± 5	0.27	64 ± 4	62 ± 6	0.78
LV SV indexed (ml/m²)	51 ± 9	51 ± 7	0.98	52 ± 9	49 ± 9	0.20
LV- mass (g)	105 ± 25	106 ± 28	0.75	101 ± 23	110 ± 26	0.12
Septum (mm)	9 (8–10)	8.5 (8–10)	< 0.05	9 (8–10)	10 (9–11)	0.12
Inferolateral wall (mm)	6 (6–7)	6 (5–7)	0.40	6 (5–7)	7 (6–7)	< 0.05
RV EDV indexed (ml/m²)	79 ± 15	82 ± 13	0.57	78 ± 13	79 ± 16	0.76
RVEF (%)	66 ± 7	64 ± 7	0.29	67 ± 6	64 ± 8	< 0.05
RV SV indexed (ml/m²)	51 ± 9	51 ± 7	0.84	52 ± 9	50 ± 9	0.28
Strain
LV-GLS (%)	− 19.6 ± 2.2	− 20.3 ± 1.5	0.09	− 20.0 ± 2.2	− 19.1 ± 2.1	0.09
LV-GCS (%)	− 19.7 ± 2.6	− 21.0 ± 1.3	< 0.01	− 20.5 ± 2.1	− 18.7 ± 2.9	< 0.01
RV-GLS (%)	− 20.5 ± 2.2	− 21.0 ± 1.7	0.18	− 20.6 ± 2.1	− 20.3 ± 2.3	0.61
RV-GCS (%)	− 18.5 ± 2.4	− 19.2 ± 1.5	0.10	− 18.9 ± 1.9	− 18 ± 2.8	0.12

Cardiac Magnetic Resonance (CMR) Measurements of Wilson Disease (WD) patients compared to Controls and WD patients without (WD-neuro⁻) and with neurological symptoms (WD-neuro⁺): LV, left ventricle; EDV, end-diastolic volume; EF, ejection fraction; SV, stroke volume; CO, cardiac output; MAPSE, mitral annular plane systolic excursion; LA, left atrium; RV, right ventricle; TAPSE, tricuspid annular plane systolic excursion; GLS, global longitudinal strain; GCS, global circumferential strain: Values are mean ± standard deviation or median (interquartile range). Differences between groups were calculated using t-test or Mann–Whitney U test

ISSN: 1532-429X