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Table 1 Physiological and cardiovascular magnetic resonance data for all subjects

From: Ultrahigh-field cardiovascular magnetic resonance T1 and T2 mapping for the assessment of anthracycline-induced cardiotoxicity in rat models: validation against histopathologic changes

 

Group 0

Control

(n = 5)

Group 1

2-week

(n = 6)

Group 2

4-week

(n = 8)

Group 3

6-week

(n = 7)

Group 4

8-week

(n = 7)

Group 5

12-week

(n = 7)

Hct (%)

58.8 ± 2.0

41.6 ± 13.0

46.3 ± 10.0

40.5 ± 12.0

43.9 ± 12.0

43.0 ± 14.0

Heart rate (min)

281 ± 30

270 ± 24

280 ± 35

271 ± 28

279 ± 51

292 ± 51

LVEDV (ml)

0.69 ± 0.05

0.73 ± 0.09

0.68 ± 0.09

0.77 ± 0.05

0.69 ± 0.09

0.63 ± 0.01

LVESV (ml)

0.18 ± 0.02

0.20 ± 0.04

0.23 ± 0.03

0.27 ± 0.04

0.24 ± 0.06

0.26 ± 0.07

LVSV (ml)

0.51 ± 0.06

0.52 ± 0.06

0.46 ± 0.10

0.50 ± 0.05

0.45 ± 0.07

0.37 ± 0.10

CO (l/min)

0.15 ± 0.01

0.14 ± 0.01

0.13 ± 0.03

0.14 ± 0.03

0.13 ± 0.03

0.10 ± 0.03*

LV mass (g)

0.66 ± 0.08

0.69 ± 0.09

0.67 ± 0.14

0.74 ± 0.11

0.64 ± 0.08

0.61 ± 0.06

LVEF(%)

73 ± 4

72 ± 3

66 ± 8

65 ± 5

65 ± 7

59 ± 9*

Native T1 (ms)

1148 ± 58

1191 ± 119

1278 ± 49

1320 ± 56*

1327 ± 82*

1316 ± 69*

T2 (ms)

10.3 ± 1

12.2 ± 1

11.4 ± 1

16.3 ± 2*

17.3 ± 5

14.0 ± 2

Partition coefficient

0.36

0.28

0.32

0.35

0.38

0.43†

ECV (%)

14.3 ± 1

15.7 ± 1

17.1 ± 2

20.3 ± 3*

21.2 ± 4*

23.2 ± 4*

  1. Values are expressed as mean or mean ± SD
  2. CO cardiac output; ECV extracellular volume fraction; Hct hematocrit; LVEDV left ventricular end-diastolic volume; LVEF left ventricular ejection fraction; LVESV left ventricular end-systolic volume; LVSV left ventricular stroke volume, min; minute
  3. *Control vs. Group subjects, P < 0.05
  4. †Group 1 vs Group 5, P < 0.05