Multi-parametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance

Table 2 Sensitivities, specificities, and accuracy values for the differentiation between different clinical entities by %normal myocardium, LGE data and by combining both

Clinical entities	Parameters	Sensitivity	Specificity	AUC	p-values
A. All patients
Athletes vs. HCM	%normal myocardium	98%	100%	0.99	0.08^§
Athletes vs. HCM	Atypical LGE	98%	83%	0.90	0.08^§
Athletes vs. HHD	%normal myocardium	67%	91%	0.84	0.001^§
Athletes vs. HHD	Atypical LGE	42%	83%	0.61	0.001^§
HHD vs. HCM	%normal myocardium	47%	98%	0.78	0.03^§
	Atypical LGE	74%	91%	0.88
	%normal myocardium and LGE*	82%	98%	0.92
HCM vs. amyloidosis	%normal myocardium	56%	91%	0.82	0.7^§
	Atypical LGE	70%	96%	0.81
	%normal myocardium and LGE**	80%	100%	0.94
B. Patients with mild to moderate hypertrophy (IVS 11–15 mm)
Athletes vs. HCM	%normal myocardium	100%	100%	1.0	0.16^§
Athletes vs. HCM	Atypical LGE	100%	75%	0.84	0.16^§
Athletes vs. HHD	%normal myocardium	83%	75%	0.86	0.003^§
Athletes vs. HHD	Atypical LGE	41%	75%	0.56	0.003^§
HHD vs. HCM	%normal myocardium	45%	100%	0.78	0.04^§
	Atypical LGE	86%	85%	0.90
	%normal myocardium and LGE*	82%	100%	0.92
HCM vs. amyloidosis	%normal myocardium	85%	50%	0.73	0.11^§
	Atypical LGE	83%	100%	0.83
	%normal myocardium and LGE**	83%	100%	0.83
C. All patients (Cut-off values derived from cohort A and applied to cohort B; mean AUC values of cohorts A&B are provided)
Athletes vs. HCM	%normal myocardium	100%	100%	0.99	0.10^§
Athletes vs. HCM	Atypical LGE	100%	67%	0.81	0.10^§
Athletes vs. HHD	%normal myocardium	73%	91%	0.84	0.008^§
Athletes vs. HHD	Atypical LGE	48%	67%	0.55	0.008^§
HHD vs. HCM	%normal myocardium	39%	100%	0.78	0.42^§
HHD vs. HCM	Atypical LGE	64%	91%	0.87	0.42^§
HCM vs. amyloidosis	%normal myocardium	56%	91%	0.83	0.38^§
HCM vs. amyloidosis	Atypical LGE	77%	68%	0.82	0.38^§

AUC area under the curve, HCM hypertrophic cardiomyopathy, HHD hypertensive heart disease, LGE late gadolinium enhancement, IVS intraventricular septum
*For the combined approach, patients with no atypical LGE were classified as HHD, whereas in patients with one or more segments with atypical LGE classification was performed by %normal myocardium
**For the combined approach, patients with ≥ 10 segments atypical LGE were classified as cardiac amyloidosis, whereas in patients with < 10 segments atypical LGE, classification was performed by %normal myocardium
^§For comparison of atypical LGE vs. %normal myocardium

ISSN: 1532-429X