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Table 2 Sensitivities, specificities, and accuracy values for the differentiation between different clinical entities by %normal myocardium, LGE data and by combining both

From: Multi-parametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance

Clinical entities Parameters Sensitivity Specificity AUC p-values
A. All patients
 Athletes vs. HCM %normal myocardium 98% 100% 0.99 0.08§
 Athletes vs. HCM Atypical LGE 98% 83% 0.90
 Athletes vs. HHD %normal myocardium 67% 91% 0.84 0.001§
 Athletes vs. HHD Atypical LGE 42% 83% 0.61
 HHD vs. HCM %normal myocardium 47% 98% 0.78 0.03§
Atypical LGE 74% 91% 0.88
%normal myocardium and LGE* 82% 98% 0.92
 HCM vs. amyloidosis %normal myocardium 56% 91% 0.82 0.7§
Atypical LGE 70% 96% 0.81
%normal myocardium and LGE** 80% 100% 0.94
B. Patients with mild to moderate hypertrophy (IVS 11–15 mm)
 Athletes vs. HCM %normal myocardium 100% 100% 1.0 0.16§
 Athletes vs. HCM Atypical LGE 100% 75% 0.84
 Athletes vs. HHD %normal myocardium 83% 75% 0.86 0.003§
 Athletes vs. HHD Atypical LGE 41% 75% 0.56
 HHD vs. HCM %normal myocardium 45% 100% 0.78 0.04§
Atypical LGE 86% 85% 0.90
%normal myocardium and LGE* 82% 100% 0.92
 HCM vs. amyloidosis %normal myocardium 85% 50% 0.73 0.11§
Atypical LGE 83% 100% 0.83
%normal myocardium and LGE** 83% 100% 0.83
C. All patients (Cut-off values derived from cohort A and applied to cohort B; mean AUC values of cohorts A&B are provided)
 Athletes vs. HCM %normal myocardium 100% 100% 0.99 0.10§
 Athletes vs. HCM Atypical LGE 100% 67% 0.81
 Athletes vs. HHD %normal myocardium 73% 91% 0.84 0.008§
 Athletes vs. HHD Atypical LGE 48% 67% 0.55
 HHD vs. HCM %normal myocardium 39% 100% 0.78 0.42§
Atypical LGE 64% 91% 0.87
 HCM vs. amyloidosis %normal myocardium 56% 91% 0.83 0.38§
Atypical LGE 77% 68% 0.82
  1. AUC area under the curve, HCM hypertrophic cardiomyopathy, HHD hypertensive heart disease, LGE late gadolinium enhancement, IVS intraventricular septum
  2. *For the combined approach, patients with no atypical LGE were classified as HHD, whereas in patients with one or more segments with atypical LGE classification was performed by %normal myocardium
  3. **For the combined approach, patients with ≥ 10 segments atypical LGE were classified as cardiac amyloidosis, whereas in patients with < 10 segments atypical LGE, classification was performed by %normal myocardium
  4. §For comparison of atypical LGE vs. %normal myocardium