Diseased patients (N = 259) | Normal controls (N = 21) | P-value | |
---|---|---|---|
Clinical data | |||
Age (years) | 54 (13) | 44 (15) | 0.001 |
Male | 196 (76) | 13 (62) | 0.163 |
Body surface area (m2) | 2.06 (0.24) | 1.86 (0.21) | < 0.001 |
Body mass index (kg/m2) | 29.4 (5.1) | 24.9 (3.2) | < 0.001 |
Heart rate (bpm) | 68 (13) | 69 (13) | 0.711 |
Systolic blood pressure (mmHg) | 131 (190 | 119 (13) | 0.019 |
Diastolic blood pressure (mmHg) | 75 (11) | 71 (12) | 0.209 |
Smoking history | 91 (36) | 6 (32) | 0.718 |
History of heart failure | 84 (33) | 0 (0) | 0.003 |
History of coronary artery disease | 48 (19) | 0 (0) | 0.038 |
Hypertension | 124 (49) | 0 (0) | < 0.001 |
Hyperlipidemia | 124 (49) | 0 (0) | < 0.001 |
Diabetes | 44 (17) | 0 (0) | 0.047 |
Function and structure | |||
LV end diastolic volume (ml/m2) | 84 (24) | 75 (13) | 0.090 |
LV end systolic volume (ml/m2) | 43 (21) | 33 (7) | 0.043 |
LV ejection fraction (%) | 51 (11) | 56 (4) | 0.042 |
LV ejection fraction < 50% | 93 (36) | 0 (0) | < 0.001 |
LV mass (g/m2) | 61 (15) | 51 (10) | 0.004 |
RV ejection fraction (%) | 53 (9) | 55 (4) | 0.283 |
Diagnosis | |||
Ischemic cardiomyopathy | 29 (11) | 0 (0) | |
Hypertrophic cardiomyopathy | 30 (12) | 0 (0) | |
Dilated cardiomyopathy | 81 (31) | 0 (0) | |
Infiltrative cardiomyopathy | 31 (12) | 0 (0) | |
Myocarditis | 17 (7) | 0 (0) | |
Valvular disease | 28 (11) | 0 (0) | |
Other myocardial diseasea | 43 (17) | 0 (0) | |
No significant findings | 0 (0) | 21 (100) | |
Tissue characterization | |||
Late gadolinium enhancement | 125 (48) | 0 | < 0.001 |
Native T1 (ms) | 990 (42) | 981 (28) | 0.356 |
Post-contrast T1 (ms) | 482 (39) | 498 (31) | 0.087 |
Extracellular volume (%) | 27.7 (5.1) | 25.9 (2.6) | 0.108 |
Strain | |||
Global longitudinal strain (%) | − 10.5 (3.5) | − 13.5 (1.9) | < 0.001 |
Global circumferential strain (%) | − 12.9 (4.1) | − 16.2 (2.4) | < 0.001 |
Global radial strain (%) | 19.6 (8.3) | 25.9 (5.8) | < 0.001 |