Fig. 6

Optimization of Absolute T2* Cut-offs for Detecting IMH and Quantifying IMH volume. ROC curves for IMH detection based on segmental analysis of T2* images obtained in the acute and chronic phases using absolute T2* cut-offs in patients are shown in A left panel. A right panel shows optimized T2* cut-off with corresponding area under the cure (AUC), sensitivity, specificity and accuracy. B left panel shows the IMH volume detected at the whole-heart level at the various absolute T2* thresholds of 5–30 ms (in increments of 5 ms) and ssT2*. B right panel shows IMH volume detected at the whole-heart level in the acute and chronic phases based on optimized absolute T2* cut-off identified in A relative to ssT2*. ROC curves for IMH detection based on segmental analysis of T2* images obtained in the acute and chronic phases using absolute T2* cut-offs in animals are shown in C left panel. C right panel shows optimized T2* cut-off with corresponding area under the cure (AUC), sensitivity, specificity and accuracy. D left panel shows the IMH volume detected at the whole-heart level at the various absolute T2* thresholds of 5–30 ms (in increments of 5 ms) and ssT2*. D right panel shows IMH volume detected at the whole-heart level in the acute and chronic phases based on optimized absolute T2* cut-off identified relative to ssT2* from segmental analysis in panel (C). *Indicates statistical significance (p < 0.05) compared to ssT2* approach, and ns represents no statistical significance