Skip to main content

Table 4 CMR parameters of patients with MD2 and FSHD1 at baseline and at follow-up

From: Progressive myocardial injury in myotonic dystrophy type II and facioscapulohumeral muscular dystrophy 1: a cardiovascular magnetic resonance follow-up study

Parameter MD2 FSHD1
Baseline (n = 31) Follow-up n = 22 p-value Baseline n = 52 Follow-up
n = 41
p value
LVEF (%) 68 ± 6 62 ± 6  < 0.01 63 ± 5 60 ± 3 0.762
LVEDV (ml) 126 ± 22 124 ± 29 0.605 128 ± 21 139 ± 34 0.131
LVEDVI (ml/cm) 0.80 ± 0.11 0.73 ± 0.15 0.275 0.70 ± 0.10 0.79 ± 0.17  < 0.01
LV mass (g) 104 ± 27 92 ± 24 0.124 99 ± 25 102 ± 24 0.630
LV mass index (g/cm) 0.60 ± 0.14 0.54 ± 0.12 0.110 0.56 ± 0.13 0.57 ± 0.12 0.524
LV stroke volume (ml) 85 ± 13 78 ± 17 0.113 80 ± 15 84 ± 18 0.084
LV stroke volume index (ml/m2) 46 ± 6 42 ± 6 0.063 45 ± 8 48 ± 9 0.245
RVEF (%) 59 ± 7 54 ± 4  < 0.01 51 ± 6 49 ± 5 0.104
RVEDV (ml) 140 ± 29 146 ± 33 0.444 160 ± 31 169 ± 28 0.470
RVEDVI (ml/m2) 76 ± 15 79 ± 14 0.456 83 ± 16 88 ± 14 0.422
RV stroke volume (ml) 82 ± 18 80 ± 19 0.932 76 ± 18 83 ± 18 0.082
RV stroke volume index (ml/m2) 44 ± 89 43 ± 8 0.852 40 ± 8 43 ± 8 0.063
LAEF (%) 60 ± 8 57 ± 7 0.392 62 ± 8 60 ± 7 0.452
LAEDV (ml) 63 ± 18 71 ± 25 0.275 54 ± 14 61 ± 14 0.021
LAEDVI(ml/m2) 35 ± 8 38 ± 25 0.288 28 ± 7 32 ± 8 0.027
LA (cm2) 21 ± 3 24 ± 5  < 0.01 19 ± 3 22 ± 3  < 0.01
RA (cm2) 21 ± 3 24 ± 5 0.040 20 ± 3 23 ± 4 0.029
Native T1 basal (ms) 1029 ± 30 1015 ± 38 p = 0.066 1010 ± 26 991 ± 24  < 0.01
Native T1 mid (ms) 1012 ± 38 998 ± 30 p = 0.258 991 ± 39 989 ± 30 p = 0.102
Native T1 apical (ms) 1018 ± 50 999 ± 32 p = 0.163 983 ± 41 970 ± 40 p = 0.203
ECV basal (%) 26 ± 3 24 ± 3  < 0.01 26 ± 3 22 ± 2  < 0.01
ECV mid (%) 26 ± 2 24 ± 2  < 0.01 26 ± 3 23 ± 3  < 0.01
ECV apical (%) 29 ± 3 26 ± 2  < 0.01 27 ± 3 24 ± 2  < 0.01
T2 basal (ms) 51 ± 2 49 ± 2  < 0.01 50 ± 4 47 ± 2  < 0.01
T2 mid (ms) 52 ± 3 49 ± 3  < 0.01 51 ± 3 47 ± 2  < 0.01
T2 apical (ms) 55 ± 4 50 ± 2  < 0.01 53 ± 3 48 ± 2  < 0.01
Cell volume basal (ml) 72 ± 18 68 ± 17 p = 0.409 71 ± 19 74 ± 22 p = 0.308
Cell volume mid (ml) 70 ± 19 76 ± 17 p = 0.553 71 ± 20 73 ± 22 p = 0.361
Fibrosis volume basal (ml) 25 ± 9 20 ± 7 p = 0.055 24 ± 8 20 ± 7 p = 0.023
Fibrosis volume mid (ml) 26 ± 7 21 ± 6  < 0.01 23 ± 7 22 ± 7 p = 0.032
GLS (%) LGE(-) patients -17.9 ± 1 -16.8 ± 1  < 0.01 -18.3 ± 1 -16.4 ± 1 p < 0.01
  1. Data are shown as mean values ± standard deviation (SD) according to the AHA-segment model. Significant differences (p < 0.05) are highlighted in bold
  2. BMI body mass index, BSA body surface area (Mosteller), HR heart rate, BP blood pressure, LVEF left ventricular ejection fraction, LVEDV left ventricular end-diastolic volume, LVEDVI eft ventricular end-diastolic volume index, LVESV left ventricular end-systolic volume, LA left atrium, RA right atrium, GLS global longitudinal strain, ECV extracellular volume fraction