Direct mitral regurgitation quantification in hypertrophic cardiomyopathy using 4D flow CMR jet tracking: evaluation in comparison to conventional CMR

Table 2 Inter-observer analysis for indirect volumetric method measurements and direct 4D flow CMR measurements

	Bland–Altman	Intraclass coefficient		Cohen’s kappa^a
	Bias [LOA]	ICC	p-value	Kappa	p-value
Indirect volumetric method
LV end-diastolic volume (mL)	− 3 [− 18, 12]	0.97	< 0.001*	–	–
LV end-systolic volume (mL)	− 6 [− 21, 10]	0.69	0.15	–	–
LV stroke volume (mL)	3 [− 18, 23]	0.91	< 0.001*	–	–
Aortic forward flow (mL)	− 3 [− 21, 15]	0.91	< 0.001*	–	–
MR volume (mL)	6 [− 19, 31]	0.80	0.003*	0.38	< 0.001*
Direct 4D flow CMR jet tracking
MR start (timeframe #)	0 [− 2, 2]	0.90	< 0.001*	–	–
MR end (timeframe #)	0 [− 1, 1]	1.00	< 0.001*	–	–
MR jet duration (no. of timeframes)	0 [− 1, 1]	0.99	< 0.001*	–	–
MR volume (mL)	− 2 [− 12, 8]	0.97	< 0.001*	0.84	< 0.001*

LOA limits of agreement, ICC intraclass coefficient, MR mitral regurgitation
Asterisk (*) denotes significant p-value < 0.05
^aCohen’s kappa was calculated for severity of MR (none, mild, moderate, severe), which was derived from MR volume

ISSN: 1532-429X