Table 5 Univariate and multivariable linear regression analysis for determinants of RV dysfunction, RV dilation, and exercise capacity in healthy controls and repaired tetralogy of Fallot (rTOF)
| Â | Univariate analysis | Stepwise multivariable analysis | ||
|---|---|---|---|---|
Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | |
Determinants of RVEF | ||||
 RV direct flow, % | 0.574 (0.448, 0.700) |  < 0.001 | 0.574 (0.448, 0.700) |  < 0.0001 |
 RV retained inflow, % | − 0.086 (− 0.476, 0.303) | 0.661 | – |  |
 RV delayed ejection flow, % | − 0.077 (− 0.377, 0.222) | 0.610 | – |  |
 RV residual volume, % | − 0.549 (− 0.681, − 0.416) |  < 0.001 | – |  |
 RV peak systolic KEiEDV, µJ/ml | 0.030 (− 0.102, 0.161) | 0.655 | – |  |
 RV average systolic KEiEDV, µJ/ml | − 0.005 (− 0.229, 0.218) | 0.963 | – |  |
 RV peak E-wave KEiEDV, µJ/ml | − 0.091 (− 0.194, 0.012) | 0.083 | – |  |
 KE discordance | − 2.111 (− 4.285, 0.062) | 0.057 | – |  |
 R-squared, multivariable |  |  |  | 0.396 |
Determinants of RV remodelling index (RVEDV/LVEDV ratio) | ||||
 RVEF, % | − 0.025 (− 0.035, − 0.016) |  < 0.001 | – |  |
 RV direct flow, % | − 0.033 (− 0.041, − 0.025) |  < 0.0001 | − 0.025 (− 0.032, − 0.017) |  < 0.001 |
 RV retained inflow, % | − 0.005 (− 0.029, 0.019) | 0.664 | – |  |
 RV delayed ejection flow, % | 0.010 (− 0.009, 0.028) | 0.304 | – |  |
 RV residual volume, % | 0.031 (0.023, 0.040) |  < 0.001 | – |  |
 RV peak systolic KEiEDV, µJ/ml | 0.004 (− 0.004, 0.012) | 0.310 | – |  |
 RV average systolic KEiEDV, µJ/ml | 0.013 (− 0.001, 0.026) | 0.071 | – |  |
 RV peak E-wave KEiEDV, µJ/ml | 0.021 (0.015, 0.026) |  < 0.001 | 0.015 (0.010, 0.020) |  < 0.001 |
 KE discordance | 0.122 (− 0.012, 0.256) | 0.075 | – |  |
 R-squared, multivariable |  |  |  | 0.492 |
Determinants of exercise capacity (% predicted peak VO2)* | ||||
 RVEF, % | 0.386 (− 0.341, 1.113) | 0.295 | – |  |
RV direct flow, % | 0.626 (0.048, 1.203) | 0.034 | 0.626 (0.048, 1.203) | 0.034 |
 RV retained inflow, % | − 0.919 (− 2.321, 0.484) | 0.197 | – |  |
 RV delayed ejection flow, % | − 0.361 (− 1.448, 0.726) | 0.512 | – |  |
 RV residual volume, % | − 0.431 (− 1.608, 0.207) | 0.183 | – |  |
 RV peak systolic KEiEDV, µJ/ml | − 0.185 (− 0.651, 0.280) | 0.431 | – |  |
 RV average systolic KEiEDV, µJ/ml | − 0.398 (− 1.219, 0.423) | 0.338 | – |  |
 RV peak E-wave KEiEDV, µJ/ml | − 0.362 (− 0.702, − 0.022) | 0.037 | – |  |
 KE discordance | − 4.138 (− 13.049, 4.773) | 0.359 | – |  |
 LV direct flow, % | 0.331 (− 0.375, 0.036) | 0.354 | – |  |
 LV retained inflow, % | − 0.631 (− 1.626, 0.363) | 0.210 | – |  |
 LV delayed ejection flow, % | − 0.399 (− 1.463, 0.666) | 0.459 | – |  |
 LV residual volume, % | 0.184 (− 0.541, 0.908) | 0.616 | – |  |
 R-squared, multivariable |  |  |  | 0.046 |