Fig. 3

Funnel plot for standardized mean difference (SMD) of native T1 values between patients with Anderson-Fabry disease and control subjects. Each dot represents a study; the y-axis represents study precision [standard error (S.E.) of effect size] and the x-axis the effect size. Large studies appear toward the top of the graph and tend to cluster near the mean effect size. Small studies appear toward the bottom of the graph and are dispersed across a range of values since there is more sampling variation in effect size estimates. The outer dashed lines indicate the triangular region within which 95% of studies are expected to lie in the absence of biases and heterogeneity