Cardiovascular magnetic resonance native T1 mapping in Anderson-Fabry disease: a systematic review and meta-analysis

Ponsiglione, Andrea; Gambardella, Michele; Green, Roberta; Cantoni, Valeria; Nappi, Carmela; Ascione, Raffaele; De Giorgi, Marco; Cuocolo, Renato; Pisani, Antonio; Petretta, Mario; Cuocolo, Alberto; Imbriaco, Massimo

doi:10.1186/s12968-022-00859-z

Journal of Cardiovascular Magnetic Resonance

Table 1 Characteristics and Imaging Data of the Included Studies

From: Cardiovascular magnetic resonance native T1 mapping in Anderson-Fabry disease: a systematic review and meta-analysis

Reference	Study design	Study type	Field strength	Sequence	ROI sampling	Quality score	LVH (%)		LVEF (%)		Native T1 (ms)
Reference	Study design	Study type	Field strength	Sequence	ROI sampling	Quality score	AFD patients	Control subjects	AFD patients	Control subjects	AFD patients	Control subjects
[15]	Prospective	Single center	1.5T	MOLLI	Mean basal-mid SAx	2, 1, 2	−	0	66 ± 6	66 ± 7	930 ± 54	1000 ± 34
[16]	Retrospective	Single center	1.5T	MOLLI	Mean 3 SAx	4, 1, 2	53	0	59 ± 11	63 ± 5	891 ± 49	966 ± 27
[18]	Prospective	Multi-center	1.5T	MOLLI	Mean 3 Sax & LAx	3, 1, 2	0	0	58 ± 9	67 ± 4	961 ± 53	1029 ± 38
[24]	Prospective	Single center	1.5T	MOLLI	Mean 16 AHA	3, 1, 2	24	0	66 ± 12	66 ± 8	903 ± 14* 888 ± 70**	1001 ± 22
[20]	Prospective	Single center	1.5T	ShMOLLI	Mean mid-septum SAx & LAx	2, 1, 2	0	0	72 ± 6	−	906 ± 68	970 ± 21
[22]	Retrospective	Single center	1.5T	ShMOLLI	Mid-septum SAx	4, 1, 2	−	0	60 ± 15	66 ± 9	863 ± 23	938 ± 21
[25]	Prospective	Single center	1.5T	ShMOLLI	Mean basal-mid-septum SAx	3, 1, 2	60	0	74 ± 6* 78 ± 7**	75 ± 7	904 ± 46* 853 ± 50**	968 ± 32
[26]	Prospective	Single center	1.5T	ShMOLLI	Mean basal-mid-septum SAx	3, 1, 2	55	0	−	−	882 ± 47	968 ± 32
[23]	Retrospective	Single center	1.5T	SASHA	Mid-septum SAx	3, 1, 2	−	0	67 ± 7	62 ± 5	1053 ± 41	1180 ± 60
[27]	Prospective	Single center	1.5T	SASHA	Mean basal-mid SAx	3, 1, 2	52	0	67 ± 5	64 ± 4	1070 ± 50	1177 ± 27
[14]	Prospective	Single center	3T	MOLLI	Mean 16 AHA	4, 1, 2	14	0	67 ± 12	67 ± 2	1112 ± 49	1232 ± 12
[17]	Prospective	Single center	3T	MOLLI	Mean 16 AHA	4, 1, 2	19	0	60 ± 5	62 ± 3	1164 ± 34	1235 ± 25
[19]	Prospective	Single center	3T	MOLLI	Mid-septum SAx	4, 1, 2	21	0	59 ± 5	60 ± 4	1170 ± 37	1238 ± 18
[21]	Prospective	Single center	3T	MOLLI	Mean 3 SAx	4, 1, 2	0	0	69 ± 7	66 ± 3	1236 ± 49	1334 ± 27

Values are expressed as mean ± standard deviation or as percentage of subjects. ROI region of interest, SAx short axis, LAx long axis, AHA American Heart Association, MOLLI modified look-locker inversion recovery, ShMOLLI shortened MOLLI, SASHA saturation-recovery single-shot acquisition, LVH left ventricular hypertrophy, LVEF left ventricular ejection fraction. *Patients without and **patients with left ventricular hypertrophy

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ISSN: 1532-429X

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