| Univariate analysis | Stepwise multivariable analysis | ||
---|---|---|---|---|
Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | |
Determinants of RV function (RVEF) | ||||
 RA area, cm2 | − 0.619 (− 0.839, − 0.398) | < 0.001 | – | 0.348 |
 TAPSE, mm | 1.362 (0.900, 1.823) | < 0.001 | – | 0.514 |
 RV GLS, % | 1.430 (1.136, 1.723) | < 0.001 | 0.596 (0.281, 0.911) | < 0.001 |
 RV direct flow, % | 0.820 (0.686, 0.954) | < 0.001 | 0.587 (0.426, 0.748) | < 0.001 |
 RV retained inflow, % | 0.076 (− 0.404, 0.556) | 0.754 | Excluded |  |
 RV delayed ejection flow, % | 0.208 (− 0.310, 0.726) | 0.428 | Excluded |  |
 RV residual volume, % | − 0.649 (− 0.779, − 0.519) | < 0.001 | – | 0.378 |
 RV peak systolic KEiEDV, µJ/ml | 0.370 (0.141, 0.600) | 0.002 | 0.198 (0.061, 0.336) | 0.005 |
 RV average systolic KEiEDV, µJ/ml | 0.747 (0.278, 1.216) | 0.002 | – | 0.802 |
 RV peak E–wave KEiEDV, µJ/ml | 0.048 (− 0.207, 0.303) | 0.710 | Excluded |  |
 KE discordance | 9.393 (5.136, 13.65) | < 0.001 | – | 0.846 |
 Fractional flow ratio | 11.964 (9.129, 14.80) | < 0.001 | – | 0.118 |
 R–squared, multivariable |  |  |  | 0.698 |
Determinants of adverse RV remodelling (Ln(RVEDV/LVEDV))* | ||||
 RVEF, % | − 0.025 (− 0.033, − 0.017) | < 0.001 | – | 0.997 |
 RA area, cm2 | 0.042 (0.034, 0.050) | < 0.001 | 0.017 (0.011, 0.023) | < 0.001 |
 TAPSE, mm | − 0.051 (− 0.073, − 0.028) | < 0.001 | − 0.019 (− 0.031, − 0.007) | 0.002 |
 RV GLS, % | − 0.049 (− 0.065, − 0.033) | < 0.001 | – | 0.520 |
 RV direct flow, % | − 0.030 (− 0.038, − 0.022) | < 0.001 | − 0.008 (− 0.013, − 0.002) | 0.007 |
 RV retained inflow, % | 0.006 (− 0.016, 0.028) | 0.589 | Excluded |  |
 RV delayed ejection flow, % | 0.005 (− 0.019, 0.028) | 0.703 | Excluded |  |
 RV residual volume, % | 0.021 (0.014, 0.028) | < 0.001 | – | 0.385 |
 RV peak systolic KEiEDV, µJ/ml | 0.003 (− 0.008, 0.014) | 0.628 | Excluded |  |
 RV average systolic KEiEDV, µJ/ml | 0.015 (–0.008, 0.037) | 0.196 | Excluded |  |
 RV peak E–wave KEiEDV, µJ/ml | 0.008 (− 0.004, 0.019) | 0.201 | Excluded |  |
 KE discordance | − 0.129 (− 0.342, 0.083) | 0.231 | Excluded |  |
 Fractional flow ratio | − 0.393 (− 0.544, − 0.241) | < 0.001 | – | 0.096 |
 R–squared, multivariable |  |  |  | 0.588 |
Determinants of exercise capacity (Ln(% predicted peak VO2))* | ||||
 RVEF, % | 0.021 (0.014, 0.028) | < 0.001 | – | 0.228 |
 RA area, cm2 | − 0.018 (− 0.028, − 0.008) | 0.001 | – | 0.418 |
 TAPSE, mm | 0.055 (0.036, 0.074) | < 0.001 | 0.035 (0.014, 0.055) | 0.001 |
 RV GLS, % | 0.036 (0.021, 0.051) | < 0.001 | – | 0.096 |
 RV direct flow, % | 0.023 (0.015, 0.030) | < 0.001 | 0.016 (0.008, 0.024) | < 0.001 |
 RV retained inflow, % | − 0.006 (− 0.025, 0.014) | 0.578 | Excluded |  |
 RV delayed ejection flow, % | 0.019 (− 0.002, 0.040) | 0.073 | Excluded |  |
 RV residual volume, % | − 0.019 (− 0.025, − 0.012) | < 0.001 | – | 0.209 |
 RV peak systolic KEiEDV, µJ/ml | − 0.003 (− 0.013, 0.007) | 0.553 | Excluded |  |
 RV average systolic KEiEDV, µJ/ml | − 0.002 (− 0.023, 0.018) | 0.823 | Excluded |  |
 RV peak E–wave KEiEDV, µJ/ml | − 0.007 (− 0.018, 0.003) | 0.164 | Excluded |  |
 KE discordance | 0.245 (0.060, 0.430) | 0.010 | – | 0.753 |
 Fractional flow ratio | 0.331 (0.193, 0.470) | < 0.001 | – | 0.641 |
 R–squared, multivariable |  |  |  | 0.361 |