Fig. 8

Visualization of thrombus formation in an aorta segment with plaque rupture using generalized Q-space imaging (GQI) in the 1% cholesterol diet + injury rabbit. Thrombus visualized under PLM (A) demonstrated the presence of lipids in both the enlarged intima (plaque) and in the thrombus. B 2D GQI slices of the thrombus with individual voxels shown, color encoded to fiber orientation along the given orientation axis. The thrombus propagated along the vessel wall while remaining attached to the plaque areas (blue). C 3D tractography reconstruction of the vessel wall and thrombus with the measured fiber orientations (axial/top view of the 3D model). The vessel wall media (green and red) and plaque regions demonstrated long-range coherence of fiber orientation, whereas the thrombus was incoherent, with short tracts of random orientation. The scale bars size in (A) and (B) is 1 mm