Fig. 3

Quantitative analysis of CMR pulmonary perfusion imaging to discriminate ≥ 70% PV stenosis and to determine the gain attributable to successful revascularization. Upper row: ROC analyses were performed to determine the relationship between signal intensity time curve measurements derived from dynamic contrast-enhanced CMR pulmonary perfusion imaging in the presence of ≥ 70% PV luminal diameter stenosis as defined by CMR angiography: time-to-peak enhancement demonstrated the highest discriminatory power resulting in a sensitivity and specificity of 93% and 95%, respectively (cut-off value, 8.0 s). Bottom row: mean change of quantitative measures of pulmonary perfusion at baseline, on day 1 and 3 months after interventional treatment of PV stenosis: for all three quantitative pulmonary perfusion measures, lung lobes with ≥ 70% PV stenosis demonstrated significantly impaired pulmonary perfusion at baseline when compared to non-stenosis dependent lung lobes and successful interventional treatment led to a significant improvement at day 1. In bottom row plots, mean ± standard error of the mean are given. FU 1 indicates follow-up at day 1; FU 2, follow-up at 3 months